034 The skin barrier on the cheek in young Chinese women severely damaged than old women in air-polluted region

Abstract

Interventions often result in statistically significant quality of life (QoL) improvement, but may not reach the threshold of clinical importance. The minimal clinically important difference (MCID) is the minimal score change of relevance clinically. We introduce the concept of 2MCID, a score change at least twice the usual threshold (i.e. 8 for DLQI), highlighting therapies changing by this higher threshold. A systematic review was conducted of the use of QoL instruments and of the impact of psoriasis treatments in randomized controlled trials (RCTs). 388 search terms were used to conduct searches in six databases adhering to PRISMA guidelines. Two assessors independently reviewed abstracts: a third resolved differences. Of 3646 screened publications, 99 articles (100 trials) involving 33,215 subjects met inclusion eligibility criteria. Of these 100 trials, 37 reported MCID; 32 DLQI, 10 SF-36 and 6 EQ-5D. 33 trials tested topical therapy, 18 systemic, 39 biologics, 9 phototherapy and 10 other interventions. For studies with treatment endpoint or assessment at 12 weeks, the interventions with the greatest average DLQI impact in each category were: Liquor Carbonis Distillate 15% (>1MCID, 5.8 pts), ciclosporin 3-5 mg/kg (>1MCID, 6.6 pts), secukinumab 300 mg (>2MCID, 11.4 pts), PUVAsol 0.6 mg/kg + isotretinoin 0.5 mg/kg (>2MCID, 11.2 pts) and educational programme (1MCID, 4 pts). Clolobetasol spray 0.05% (8 points, 4 weeks), ustekinumab 90 mg (8, 12), etanercept 50 mg (8.7, 24) and MTX 15 mg (8.7, 16) also reached 2MCID. The concept of '2MCID' adds meaning to score change when comparing therapies and results across different QoL instruments, though this requires further validation. However secukinumab and PUVAsol + isotretinoin both reached 2MCID at 12 weeks, according well with clinical experience.

Transepidermal water loss (TEWL): Environment and pollution—A systematic review

“…Kim et al. 27 also looked at how chronic exposure to PM may negatively affect skin integrity in younger and older subjects. They recruited 50 younger women aged 25–35 years and 50 older women aged 55–65 years in an industrial region and compared them to an equivalent control population in Kunming, an area with much less pollution.…”

“…Kim et al 27 . also looked at how chronic exposure to PM may negatively affect skin integrity in younger and older subjects.…”