0540 Upper Airway Stimulation for Obstructive Sleep Apnea

Pomerantz, Jonathan; Freedom, Thomas; Nickley, K; Bhayani, Mihir K.; Gerber, Mark E.; Freedman, Neil; Viola-Saltzman, Mari

doi:10.1093/sleep/zsy061.539

Cited by 2 publications

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“…However, adherence to the therapy remains limited despite advances in quieter pumps or softer masks (Rotenberg et al 2016 ). For this reason, hypoglossal nerve stimulation (HNS), which modulates the airway through neural stimulation of the genioglossus muscle (causing tongue protrusion), has been developed as an alternative treatment (Schwartz et al 2014 ; Pomerantz et al 2018 ; Sturm et al 2020 ; Zhu 2020 ; Eastwood et al 2020 ). To date, HNS is an invasive technique that requires an electrode in direct contact with the hypoglossal (cranial XII) nerve, as well as a battery placed in the chest to run the electrical stimulation (Manchanda 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

et al. 2023

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Background Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, temporal interference stimulation, can overcome depth and focality issues. Methods Here, we implement a novel form of temporal interference, bilateral temporal interference stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement. Results Comparing bilateral temporal interference stimulation with unilateral temporal interference stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation. Conclusions During first-in-man studies, temporal interference stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea. These results suggest a high clinical potential for the use of temporal interference in the treatment of obstructive sleep apnea and other diseases as a safe, effective, and patient-friendly approach. Trial registration The protocol was conducted with the agreement of the International Conference on Harmonisation Good Clinical Practice (ICH GCP), applicable United States Code of Federal Regulations (CFR) and followed the approved BRANY IRB File # 22-02-636-1279.

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Section: Introductionmentioning

confidence: 99%

Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

et al. 2023

View full text Add to dashboard Cite

show abstract

“…However, adherence to the therapy remains limited despite advances in quieter pumps or softer masks (Rotenberg et al, 2016). For this reason, hypoglossal nerve stimulation (HNS), which modulates the airway through neural stimulation of the genioglossus muscle (causing tongue protrusion), has been developed as an alternative treatment (Schwartz et al, 2014;Pomerantz et al, 2018;Sturm et al, 2020;Zhu et al, 2020;Eastwood et al, 2020). To date, HNS is an invasive technique that requires an electrode in direct contact with the hypoglossal (cranial XII) nerve, as well as a battery placed in the chest to run the electrical stimulation (Manchanda et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea Improves with Non-invasive Hypoglossal Nerve Stimulation using Temporal Interference

Missey

Ejneby

Ngom

et al. 2023

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Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep nerve targets and the stimulation focality to offer selectivity. It is therefore rarely employed as the primary selected nerve stimulation method. We have previously demonstrated that a new stimulation technique, Temporal Interference (TI) stimulation, can overcome depth and focality issues. Here, we implement a novel form of TI, bilateral TI (bTI) stimulation, for bilateral hypoglossal nerve stimulation in rodents and humans. Pairs of electrodes are placed alongside both hypoglossal nerves to stimulate them synchronously and thus decrease the stimulation amplitude required to activate hypoglossal-nerve-controlled tongue movement. Comparing bTI stimulation with unilateral TI stimulation, we show that it can elicit the same behavioral and electrophysiological responses at a reduced stimulation amplitude. Traditional transcutaneous stimulation evokes no response with equivalent amplitudes of stimulation. During first-in-man studies, TI stimulation was found to be well-tolerated, and to clinically reduce apnea-hypopnea events in a subgroup of female patients with obstructive sleep apnea (OSA). These results suggest a high clinical potential for the use of TI in the treatment of OSA and other diseases as a safe, effective, and patient-friendly approach.

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0540 Upper Airway Stimulation for Obstructive Sleep Apnea

Cited by 2 publications

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Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference

Obstructive Sleep Apnea Improves with Non-invasive Hypoglossal Nerve Stimulation using Temporal Interference

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