070 Acute Kidney Injury in Coronary Care Unit: Prevalence, Aetiologies and Outcomes

Abstract

Peroxiredoxin 3 (PRX3) as a mitochondrial antioxidant regulates apoptosis in various cancers. Whether tubular PRX3 could predict recovery of renal function following acute kidney injury (AKI) remains unknown. A retrospective cohort study included 54 hospitalized patients who had AKI with biopsy-proven acute tubular necrosis (ATN). The study outcome was renal function recovery within 6 months. Of the 54 enrolled patients, 25 (46.3%) had preexisting chronic kidney disease (CKD) and 33 (61%) recovered renal function. Tubular PRX3 expression was higher in patients with ATN than those without renal function recovery. In multivariate Cox regression analysis, high PRX3 expression was independently associated with a higher probability of renal function recovery (adjusted hazard ratio 8.99; 95% CI 1.13-71.52, P ¼ 0.04). Furthermore, the discriminative analysis also showed that high tubular PRX3 expression was associated with a higher probability of renal function recovery from ATN. Therefore, tubular PRX3 in combination with conventional predictors can further improve recovery prediction and may help with risk stratification in AKI patients with pre-existing CKD.