Abstract:mutation Vcc (Vacterl/caudal regression/Currarino syndromelike) exhibit a pleiotropic phenotype including abnormalities of cardiac, skeletal and limb development, in addition to renal agenesis. Here we report abnormalities of gonad development in homozygous mutants. From early stages, Vcc/Vcc embryos contain gonads longer than controls and by 13.5 dpc this increased length is evidenced by an increase in the number of testis cords.The gene mutated in Vcc, Pcsk5, encodes a proprotein convertase that is thought t… Show more
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