094 Outpatient Parenteral Antibiotic Therapy for Infective Endocarditis

Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies

“…Data from previous reports on cases of streptococcal endocarditis treated with ceftriaxone including hospital therapy and OPAT were compared with the results of our study in terms of the duration and dosing regimens of ceftriaxone and the incidence of adverse reactions with this therapy (Table 5). Most reports have documented microbiological and clinical cure rates approximating 100%, showing the efficacy of ceftriaxone regardless of whether the patient received inpatient or outpatient care [18,[20][21][22][23][24][25][26]. Patient characteristics were similar among these reports, and efficacy rates were 88-100%, demonstrating ceftriaxone to be effective.…”

“…Because the once-daily dosing regimen recommended by the AHA allows outpatient therapy, OPAT with ceftriaxone or other drugs in patients with infectious endocarditis has been reported [13,17]. Although indications for OPAT vary among reports, commonly cited requirements include the absence of complications of infectious endocarditis, known causal organism and sensitivity, and support from the family [13,17,18]. Although careful selection of patients is necessary when OPAT is used for infectious endocarditis, the safety and efficacy of OPAT are expected to be equivalent to those of inpatient treatment [19].…”