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Danesh, Hoseinali; Ghasabeh, Saeid Rahimi; Rounasi, Ramin; Zarepur, Ehsan; Abdolrazaghnejad, Ali

doi:10.26655/jmchemsci.2022.2.10

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…The mean percentage of lymphocytes in patients with severe pulmonary involvement was 17.50 ± 9.62, and in patients with mild pulmonary involvement was 26.72 ± 17.23, which was significantly different (P = 0.014; Table 2). Discussion COVID-19 is currently the seventh member of the Coronaviridae family (1)(2)(3)(4). The study of clinical, laboratory, and imaging characteristics of patients with COVID-19 improves our understanding of patients' conditions and enhances the process of clinical management.…”

Section: Resultsmentioning

confidence: 99%

“…All of these epidemics probably began with the transmission of the virus from animals to humans. The leading cause of death is usually acute atypical pneumonia (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

“…The number of cases infected with COVID-19 is increasing rapidly. As of September 2020, more than 32 000 000 cases of COVID-19 infection have been reported in China and in other parts of the world with a mortality rate of about 2 percent (1,2,(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Risk factors, clinical, and laboratory characteristics of patients with a diagnosis of COVID-19

Edalatkhah

Khorshidi

Mohammadi

et al. 2022

J Emerg Pract Trauma

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Objective: An outbreak of coronavirus disease 2019 (COVID-19) occurred in late 2019. A better understanding of this disease will help us in preventing and managing it. This study evaluated the risk factors and clinical and laboratory characteristics of patients admitted to Shahid Sadoughi hospital in Yazd with a diagnosis of COVID-19. Methods: This cross-sectional study was conducted on patients with the diagnosis of COVID-19 admitted to Shahid Sadoughi hospital in Yazd in May 2020, Iran. Patients’ clinical information, including their symptoms at admission, history of smoking or drug/ alcohol abuse, history of Td (tetanus, diphtheria) vaccine, radiographic/computed tomography (CT) scan findings, and blood oxygen saturation, was recorded. The patients were also asked about their previous history of diabetes, hypertension, autoimmune disorder, and cancer or history of diseases in heart, lung, liver, and thyroid. Laboratory findings, height, weight and body mass index of the patients were also recorded. Statistical analyses were performed using SPSS 21. Results: The mean age of 86 patients enrolled in the study was 61.40±17.37 years, of which 56 (65.11%) had mild pulmonary involvement and 30 (34.89%) had severe pulmonary involvement, according to CT scan results. Also, 26 (30.2%) of all patients had diabetes and about 30 (36%) had high blood pressure, but current smokers (6%) were rare. In patients with severe pulmonary involvement, the level of neutrophil, creatinine, and lactate dehydrogenase (LDH) was higher than patients with mild pulmonary involvement. Out of 56 patients with mild pulmonary involvement, 47 patients had a history of Td vaccination in the last 5 years. Only one patient in the severe group had a history of Td vaccination. Conclusion: A lower percentage of blood lymphocytes as well as higher levels of neutrophils, creatinine, and LDH were observed in patients with severe pulmonary involvement. Numerous factors, especially more prominent laboratory abnormalities, determine the severity of the disease, and a better understanding of these factors can help physicians know the severity of the disease and its prognosis. These findings help us to further clarify the characteristics of COVID-19. Also, the effect of Td vaccine should be investigated in future studies.

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Section: Resultsmentioning

confidence: 99%

“…All of these epidemics probably began with the transmission of the virus from animals to humans. The leading cause of death is usually acute atypical pneumonia (1)(2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk factors, clinical, and laboratory characteristics of patients with a diagnosis of COVID-19

Edalatkhah

Khorshidi

Mohammadi

et al. 2022

J Emerg Pract Trauma

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Preliminary Results of Iran Premature Coronary Artery Disease (IPAD study) and Implementation of IPAD Biobank: A Case-Control Study

Zarepur,

Mohammadifard,

Nedaeinia

et al. 2024

Arch Iran Med

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Background: Iran Premature Coronary Artery Disease (IPAD) is one of the first and largest studies of its kind in Asia that investigates different aspects of premature coronary artery disease (PCAD) in different ethnic groups in multiple cities. In this paper, we aim to describe the IPAD biobank establishment and present some preliminary results of the IPAD study. Methods: This case-control study was conducted on patients with documented angiography from different ethnicities in more than ten cities of Iran (males aged 60 years and below and females aged 70 years and below). Patients with coronary artery stenosis of more than 75% in at least one vessel (or left-main stenosis of more than 50%) were defined as the case group and patients with normal coronary angiography were considered as the control group. In addition to completing questionnaires and performing physical measurements, samples of serum, buffy coat, plasma, whole blood, saliva, urine, and feces were stored in the freezer at -80 °C. Results: The mean age of patients was 51.1±8.2, of which 43% were women. There were 1221 people in the control group and 1702 in the case group. Our enrollment is completed and data entry and transferring biosamples from different cities is still ongoing. About 30000 biosamples of different ethnicities are saved in the IPAD biobank. Conclusion: This study aims to develop a high-quality biobank and facilitate research on different aspects of PCAD, especially gene-environment interaction regarding ethnicity.

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Cited by 2 publications

References 17 publications

Risk factors, clinical, and laboratory characteristics of patients with a diagnosis of COVID-19

Risk factors, clinical, and laboratory characteristics of patients with a diagnosis of COVID-19

Preliminary Results of Iran Premature Coronary Artery Disease (IPAD study) and Implementation of IPAD Biobank: A Case-Control Study

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