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Abstract

Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p -nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electronic spectra studies, 1 H NMR spectroscopy, and EPR studies. Derived complexes are exactly non-electrolyte in nature in Dimethylformamide solution because of their lower conductance values. The IR data tells us the association of C=N nitrogen atom in coordination to the metal ion. Electronical studies and magnetic measurements suggested the octahedral geometry around metal ion under investigation. The EPR spectral data shows additional proof for the octahedral geometry. The nucleolytic cleavage of the reported compounds was checked upon pUC18 DNA by gel -electrophoresis method. In this study, anti-oxidant and anti-microbial activities have also been evidently studied. The compounds show exact growth inhibitory activity over bacteria such as S. aureus, E. coli, B. subtilis and K, pneumonia than derived free ligands. INTRODUCTION:The success of developing cisplatin as an effectual anticancer agent has drawn the notice of numerous bio-inorganic chemists en route to preparing the numerous transition metal complexes with enhanced anticancer efficacy 1 . Even though there are several biological issues in anticancer cells, which includes Ribonucleic acid, protein or enzyme and is admitted universally that Deoxy Ribonucleic acid is the prime acheivement for several anticancer drugs.