1-(1,3-Benzothiazol-2-yl)propan-2-ol

Akkurt, Mehmet; Baryala, Yamna; Zerzouf, Abdelfettah; Salem, Mohamed A.; Essassi, E. M.; Büyükgüngör, Orhan

doi:10.1107/s1600536805026437

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…1. All bond lengths and angles (Table 1) are similar to those found for 1-(1,3benzothiazol-2-yl)propan-2-ol (Akkurt et al, 2005). For the first molecule in the asymmetric unit, the S1/C1-C6/N1/C7/O1/ C8 fragment of the benzothiazole moiety is essentially planar, with maximum deviations of À0.031 (2) and 0.028 (2) Å for atoms O1 and N1 respectively.…”

Section: Commentsupporting

confidence: 71%

Methyl 2-oxo-2,3-dihydro-1,3-benzothiazole-3-acetate

Akkurt

Yıldırım

Baryala³

et al. 2005

Acta Cryst E

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Section: Commentsupporting

confidence: 71%

Methyl 2-oxo-2,3-dihydro-1,3-benzothiazole-3-acetate

Akkurt

Yıldırım

Baryala³

et al. 2005

Acta Cryst E

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“…compounds (Akkurt et al, 2005;Ö ztü rk Yıldırım et al, 2006). In the absence of classical hydrogen bonds, the crystal packing ( Fig.…”

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confidence: 99%

DimethylN-(4-phenyl-1,3-thiazol-2-yl)dithioimidocarbonate

et al. 2006

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Structure of N-(1,3-Benzothiazol-2-yl)-N-[1-(piperidin-4-ylmethyl)-4,5-dihydro-1H-imidazol-2-yl]amine, C16H21N5S

et al. 2006

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2-Arylamino-2-imidazolines have an interesting chemistry, 1,2 and are effective pharmacophores in medicinal chemistry. 2-Arylamino-2-imidazolines, particularly 2,6dichlorophenylamino-2-imidazoline (clonidine), have a pronounced, hypotensive action, which is coupled with a sedative action. Moreover, some of these compounds also have a more or less pronounced analgesic action, which, however, because of the simultaneous existence of the hypotensive action and the depressant action on the central nervous system, was considered to be unexploitable. 3 In this study, as the starting material, dimethyl N-aryldithioimidocarbonate (1) was synthesized from carbon disulfide, aromatic amine, and methyl iodide in the presence of concentrated aqueous NaOH. The synthesis of N-(1,3-benzothiazol-2-yl)-N-(4,5-dihydro-1Himidazol-2-yl)amine (2) was carried out by both conventional heating and by microwave irradiation according to cited references. 4 Its piperidine-4-yl methyl derivative (3) was synthesized by treatments with piperidine and formaldehyde.A solution of N-(1,3-benzothiazol-2-yl)-N-(4,5-dihydro-1Himidazol-2-yl)amine (2) (0.01 mol) in methanol (20 mL) was stirred at room temperature for 2 h with aqueous formaldehyde (35%; 0.015 mol) and 0.01 mol piperidine (1 mL, d: 0.86 g cm -3 ). The solvent was removed on a rotary evaporator. The residue was mixed with methanol, and the precipitate formed was filtered and then recrystallized from chloroform (yield 67%, mp 432 K).

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1-(1,3-Benzothiazol-2-yl)propan-2-ol

Abstract: Key indicatorsSingle-crystal X-ray study T = 296 K Mean (C-C) = 0.003 Å R factor = 0.042 wR factor = 0.118 Data-to-parameter ratio = 17.4For details of how these key indicators were automatically derived from the article, see

Cited by 3 publications

References 8 publications

Methyl 2-oxo-2,3-dihydro-1,3-benzothiazole-3-acetate

Methyl 2-oxo-2,3-dihydro-1,3-benzothiazole-3-acetate

DimethylN-(4-phenyl-1,3-thiazol-2-yl)dithioimidocarbonate

Structure of N-(1,3-Benzothiazol-2-yl)-N-[1-(piperidin-4-ylmethyl)-4,5-dihydro-1H-imidazol-2-yl]amine, C16H21N5S

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