1,1,3 Tricyano-2-amino-1-propene (Triap) stimulates choline acetyltransferase activity in vitro and in vivo

Paul, Jes; DaVanzo, John P.

doi:10.1016/0165-3806(92)90212-f

Cited by 12 publications

(1 citation statement)

References 18 publications

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“…Moreover, malononitriles exhibit a range of biological activities, including enhancing nucleoproteins in cells, regulating RNA synthesis in neurons and nerve tissues, promoting nerve tissue regeneration, stimulating the biosynthesis of the neurotransmitter acetylcholine (ACh), influencing learning and memory processes, and mitigating amnesia following electric shock. These multifaceted properties and biological activities highlight the importance and potential applications of malononitriles in various fields, from pharmaceuticals to neuroscience [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Crystal Structure, Hirshfeld Surface, and Void Analysis of a Malononitrile Derivative Compound

2023

Proceeding Book of 2nd International Conference on Contemporary Academic Research ICCAR 2023

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Malononitriles and their benzylidene derivatives represent a broad class of organic compounds celebrated for their diverse pharmacological activities. Their pivotal role in condensation reactions, owing to the reactivity of the active nucleophilic methylene group, holds significance across various industries, including medicine, industry, and agriculture. The structural analysis of the benzylidenemalononitrile derivative, C11H8N2, reveals an approximate planar configuration (r.m.s. deviation for all non-H atoms = 0.023 Å) with no significant intermolecular interactions. In the crystal structure, weak aromatic π-π stacking [centroid-centroid separation = 4.060 (8) Å] is evident between inversion-related pairs of central benzene rings. A comprehensive investigation of molecular interactions within the crystal was performed using Hirshfeld surface analysis and 2D fingerprinting. The quantified 2D plots of intermolecular atom contacts reveal values for N⋯H (39.6%), H⋯H (26.2%), C⋯H (18.7%), and C⋯C (13.6%). Furthermore, a void analysis was conducted to appraise the mechanical stability of the crystals. Evaluation of electron densities from spherical and symmetric atoms within the asymmetric unit revealed the absence of significant voids, thereby affirming the mechanical integrity of the crystal. The outcome of this analysis provides valuable insights into the structure and properties of the benzylidenemalononitrile derivative, shedding light on its potential applications in various fields.

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Section: Introductionmentioning

confidence: 99%

Insights into the Crystal Structure, Hirshfeld Surface, and Void Analysis of a Malononitrile Derivative Compound

2023

Proceeding Book of 2nd International Conference on Contemporary Academic Research ICCAR 2023

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Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism

et al. 1997

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Neurotrophic factor therapy for nervous system degenerative diseases

Hefti¹

1994

J. Neurobiol.

257

119

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The ability of neurotrophic factors to regulate developmental neuronal survival and adult nervous system plasticity suggests the use of these molecules to treat neurodegeneration associated with human diseases. Solid rationales exist for the use of NGF and neurotrophin-3 in the treatment of neuropathies of the peripheral sensory system, insulin-like growth factor and ciliary neurotrophic factor in motor neuron atrophy, and NGF in Alzheimer's disease. Growth factors have been identified for neurons affected in Parkinson's disease, Huntington's disease, and acute brain and spinal cord injury. Various strategies are actively pursued to deliver neurotrophic factors to the brain, and develop therapeutically useful molecules that mimic neurotrophic factor actions or stimulate their production or receptor mechanisms.

show abstract

1,1,3 Tricyano-2-amino-1-propene (Triap) stimulates choline acetyltransferase activity in vitro and in vivo

Cited by 12 publications

References 18 publications

Insights into the Crystal Structure, Hirshfeld Surface, and Void Analysis of a Malononitrile Derivative Compound

Insights into the Crystal Structure, Hirshfeld Surface, and Void Analysis of a Malononitrile Derivative Compound

Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism

Neurotrophic factor therapy for nervous system degenerative diseases

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