1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Xu, Zhi

doi:10.1016/j.ejmech.2020.112686

Cited by 84 publications

(30 citation statements)

References 110 publications

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“…Moreover, 1,2,3-triazole could form diverse non-covalent interactions, such as hydrogen bonds, van der Waals forces, and dipole-dipole bonds with various enzymes, proteins, and receptors (Bonandi et al, 2017;Bozorov et al, 2019). Hence, 1,2,3-triazole derivatives exhibit a variety of promising biological properties, including antibacterial (Zhang, 2019;Xu, 2020), antimalarial (Chu et al, 2019;Feng et al, 2020), antitubercular (Zhang et al, 2017;Yan et al, 2020), antiviral (Rani et al, 2020;Feng et al, 2021), and anticancer (Lal and Yadav, 2018;Slavova et al, 2020) activities. For example, 1,2,3-triazoles could exert the anticancer potential by inducing the cell cycle arrest and apoptosis of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Liang

Sun

et al. 2021

Front. Pharmacol.

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Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates remain extremely high, calling for an urgent need to develop novel anti–lung cancer agents. 1,2,3-Triazole could be readily interact with diverse enzymes and receptors in organisms through weak interaction. 1,2,3-Triazole can not only be acted as a linker to tether different pharmacophores but also serve as a pharmacophore. This review aims to summarize the recent advances in 1,2,3-triazole–containing compounds with anti–lung cancer potential, and their structure–activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti–lung cancer candidates.

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Section: Introductionmentioning

confidence: 99%

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Liang

Sun

et al. 2021

Front. Pharmacol.

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“…The biological properties of triazole derivatives are very diverse. Currently, among the most widely studied types of activity are: antibacterial [ 14 , 15 ], antiviral [ 16 ], and anticancer [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

et al. 2021

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Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5-aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their optical properties by using UV absorption and fluorescence emission spectroscopies revealed that all molecules possess fluorescence properties with the values of the Stokes shift more than 100 nm. The photophysical behavior of the two most promising triazoles in polar and non-polar solvents was also studied.

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“…[5] The 1,2,3-triazoles have attracted much more interest due to their extensive biological and pharmaceutical properties, including anticancer, [6] antitubercular, [7] antiinflammatory, [8] antioxidant, [9] antifungal, [10] and antibacterial. [11] The 1,2,3-triazole nucleus is featured in marketed drugs (Figure 1). The Mubritinib 1 has shown its effectiveness as anticancer medicament [12] for curing breast, bladder, kidney, and prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

[Et₃NH][HSO₄] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

Siddiqui

Nagargoje

Raza

et al. 2022

Journal of Heterocyclic Chem

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A series of new 1,2,3‐triazolidene‐indolinone derivatives (17a‐j) were designed and synthesized via [Et3NH] [HSO4] catalyzed solvent‐free approach. The synthesis strongly relied on Knoevenagel condensation of 1,4‐disubstituted 1,2,3‐triazolyl aldehydes (15a‐j) and oxindole (5). The solvent‐free approach and Brønsted acidity of [Et3NH] [HSO4] ionic liquid increased the rate of reaction and provided the corresponding 1,2,3‐triazolidene‐indolinone derivatives (17a‐j) in excellent yields. The reusability of ionic liquid is also established with persistent effective yields up to four cycles. These novel 1,2,3‐triazolidene‐indolinone derivatives may exhibit potential biological response due to the presence of potent moieties and presence of triazolidene‐exocyclic double bond.

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1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Cited by 84 publications

References 110 publications

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

[Et₃NH][HSO₄] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

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1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)

Cited by 84 publications

References 110 publications

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties

[Et3NH][HSO4] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives

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[Et₃NH][HSO₄] catalyzed solvent‐free synthesis of new 1,2,3‐triazolidene‐indolinone derivatives