1,2,3-Triazole Derivatives with Anti-breast Cancer Potential

Abstract

Breast cancer is one of the most prevalent malignant diseases and one of the main mortality causes among women across the world. Despite advances in chemotherapy, drug resistance remains major clinical concerns, creating an urgent need to explore novel anti-breast cancer drugs. 1,2,3-Triazole is a privileged moiety, and its derivatives could inhibit cancer cell proliferation, and induce the cell cycle arrest and apoptosis. Accordingly, 1,2,3-triazole derivatives possess profound activity against various cancers including breast cancer. This review summarizes the latest progresses related to the anti-breast cancer potential of 1,2,3-triazole derivatives, covering articles published from January 2017 to December 2021. The mechanisms of action and structure-activity relationships (SARs) are also discussed for further rational design of more effective candidates.

Study of the Molecular Architectures of 2-(4-Chlorophenyl)-5-(pyrrolidin-1-yl)-2H-1,2,3-triazole-4-carboxylic Acid Using Their Vibrational Spectra, Quantum Chemical Calculations and Molecular Docking with MMP-2 Receptor

“…(6) New relationships between the theoretical scaled and experimental ν as (C-H) stretching wavenumbers and the scaled and experimental 1 H NMR chemical shifts were established in 1b. (7) Molecular docking calculations reveal four H-bonded sites of 1b with ASP185, LYS44, LEU49 and VAL51 amino acids of the MMP-2 matrix metalloproteinase. The carboxylic group seems to play an important role through its two H-bonds to LEU49 and VAL51 residues, which fix our molecule to the amino acid chain stabilizing the system.…”

“…This heterocyclic class of compounds are considered as amide bioisosteres that can form diverse non-covalent interactions, such as Van der Waals forces and hydrogen bonds with various proteins, enzymes, and receptors with high resistance to enzymatic degradation [ 1 , 2 ]. This fact allows the potential use of these compounds in medicinal chemistry [ 3 ], and therefore, they are widely synthesized and tested [ 3 , 4 , 5 , 6 , 7 ]. They have received considerable attention in drug discovery for the development of anticancer agents, especially for lung [ 5 ] and breast [ 7 ] cancers, and as potential antifungal agents [ 8 ].…”

“…This fact allows the potential use of these compounds in medicinal chemistry [ 3 ], and therefore, they are widely synthesized and tested [ 3 , 4 , 5 , 6 , 7 ]. They have received considerable attention in drug discovery for the development of anticancer agents, especially for lung [ 5 ] and breast [ 7 ] cancers, and as potential antifungal agents [ 8 ]. In addition, the 1,2,3-triazole ring possesses low multidrug resistance, low toxicity, high bioavailability, and stability in both acidic and basic conditions.…”

Peculiarities of the Spatial and Electronic Structure of 2-Aryl-1,2,3-Triazol-5-Carboxylic Acids and Their Salts on the Basis of Spectral Studies and DFT Calculations

“…Due to this ability, triazoles are being widely tested for different biological activities, as well as for the synthesis of hybrid structures with drugs to enhance their binding to cellular receptors [ 3 ]. This fact allows the potential use of these compounds in medicinal chemistry [ 4 , 5 , 6 , 7 , 8 ].…”

Structural Study of a La(III) Complex of a 1,2,3-Triazole Ligand with Antioxidant Activity

“…This arrangement finds support in several previously reported lanthanide(III) coordination complexes with carboxylic acid derivatives [14,21]. 1,2,3-triazoles (Figure 2) have been extensively studied for their antimicrobial, anticancer, antioxidant, etc., activities [15][16][17][18][19]. This wide range of pharmacological effects is due to their good accessibility; the ease with which their specific structures can be modified with a great variety of substitution patterns; and their photochemical and physicochemical properties, such as a high dipole moment, molecular rigidity, and intermolecular interactions (dipole-dipole, hydrogen bonds, and π-stacking) with biotargets.…”