1,2,3-Triazoles

Acceptorless Dehydrogenative Synthesis of Pyrimidines from Alcohols and Amidines Catalyzed by Supported Platinum Nanoparticles

“…Selective catalytic transformation of alcohols, which are readily available and sustainable substrates, to fine chemicals is a growing area of interest in catalysis, organic synthesis, and green sustainable chemistry. ,− One representative example of the transformation of alcohols to fine chemicals is the catalytic one-pot synthesis of nitrogen-containing heterocycles (indoles, − quinolines, , pyrroles, − pyridines, − pyrimidines, − and quinazolines), which have broad applications as pharmaceutical and flavoring agents, agrochemicals, and other functional chemicals. , The methods are based on AD reactions of alcohols that initially form carbonyl compounds, which are then transformed to products through multiple condensation/dehydrogenation reactions occurring in the same vessel. A recent advance made in this area is the synthesis of 2,4,6-trisubstituted-pyrimidines from primary and secondary alcohols, along with amidines using homogeneous transition metal catalysts with a basic additive (KO t Bu).…”

Synthesis of 1-arylsulfonyl-1,2,3-triazoles from (Z)-arylvinyl bromides by sequential elimination–cycloaddition reaction

“…According to the previous report 14 In summary, 1-arylsulfonyl-1,2,3-triazoles can be synthesized from easily prepared (Z)-arylvinyl bromides by onepot procedure involving elimination of HBr from the substrates under the action of KOH and subsequent CuBrcatalyzed cycloaddition reaction between the intermediate arylacetylenes and sulfonyl azides.…”

“…9 Accordingly, finding efficient synthesis methods of N-sulfonyltriazoles from easily accessible starting materials is a continuous necessity. Conventionally, copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) [10][11][12][13][14][15][16][17] is an efficient synthetic tool for the construction of 1,2,3-triazoles. However, the employment of sulfonyl azides resulted in apparently different outcomes and generated in situ a reactive ketenimine intermediate by ring-opening rearrangement of N-sulfonyltriazole-copper species.…”

Synthesis of Heterocycles Mediated by Benzotriazole. 1. Monocyclic Systems

“…The rich chemistry of benzotriazole derivatives can be effectively applied to modify functional groups already attached to the pyridine ring. In an example of such reactions shown in Scheme , the anion generated from thioimidate 545 upon its treatment with NaH adds to the double bond of 4-vinylpyridine.…”