1,2,3-Triazoles and their metal chelates with antimicrobial activity

Abstract

The emergence of drug-resistant bacterial and fungal pathogens has highlighted the urgent need of innovative antimicrobial therapeutics. Transition metal complexes with biologically active ligands (coumarins, terpyridines, triazoles, uracils, etc.) have long been investigated for antimicrobial activity. 1,2,3-Triazoles and their molecular derivatives are well known for a plethora of physiological activities, including antibacterial and antifungal. The aim of the present mini-review is to inform the reader about research conducted on potential antimicrobial 1,2,3-triazole complexes with transition metals. What the authors find surprising is how little such research and experimentation has actually been performed and reported in scientific literature. The goal is to highlight research efforts up to now and impress upon the reader the vast perspectives for novel, effective medicinal substances hidden in this yet unexplored field.

Quasi-Podands with 1,2,3-Triazole Rings from Bile Acid Derivatives: Synthesis, and Spectroscopic and Theoretical Studies

“…Previous research by Ghosh et al has described similar connections achieved using cholesterol derivatives. Interestingly, these compounds exhibit The structural characterization of all synthesized compounds was accomplished through analysis of their 1 H and 13 C NMR, FT-IR, and ESI-MS spectra. In addition, PM5 calculations were conducted for each compound to further explore their properties and characteristics.…”

“…1 H NMR (400 MHz, CDCl 3 ): δ ppm 5.08 (s, 1H, 12β-H), 4.88−4.80 (m, 1H, 3β-H), 3.66 (s, 3H, −OCH 3 ), 2.89 (s, 1H, − C�CH), 2.11 (s, 3H, 12α-OAc), 0.91 (s, 3H, CH 3 -19), 0.80 (d, J = 6.3 Hz, 3H, CH 3 -21), 0.72 (s, 3H, CH 3 -18). 13 Methyl 3α-Propynoyloxy-7α,12α-diacetoxy-5β-cholan-24-oate (6). Oil (153 mg, 30%), 1 H NMR (400 MHz, CDCl 3 ): δ ppm 5.09 (s, 1H, 12β-H), 4.92−4.91 (d, J = 3.1 Hz, 1H, 7β-H), 4.76−4.68 (m, 1H, 3β-H), 3.66 (s, 3H, −OCH 3 ), 2.91 (s, 1H, −C�CH), 2.15 (s, 1H, 7α-OAc), 2.09 (s, 1H, 12α-OAc), 0.92 (s, 3H, CH 3 -19), 0.81 (d, J = 6.4 Hz, 3H, CH 3 -21), 0.73 (s, 3H, CH 3 -18).…”

“…Moreover, the bonds that are formed are resistant to cleavage even by proteases. The result may be triazole systems peptide bond analogues. , Literature data show that these are 1,2,3-triazole compounds characterized by unique pharmacotherapeutic effects, especially antihypertensive, antimalarial, antioxidant, antidepressant, antimicrobial, anti-inflammatory, and anticancer effects. − The “click” method was used to obtain new steroid conjugates containing 1,2,3-triazole rings.…”

Ethynyl-substituted benzosiloxaboroles: the role of C(π)⋯B interactions in their crystal packing and use in Cu(i)-catalyzed 1,3-dipolar cycloaddition

“…For example, vicinal diaryl triazoles were found to be promising tubulin polymerization inhibitors, COX-2 inhibitors, and CB1 receptor antagonists. 10 Essramycin (Scheme 2), is (1,2,4-triazolo)pyrimidine derivative active against several Gram-positive and Gram-negative bacteria such as Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, E. coli, and Pseudomonas aeruginosa. 11 Triazole-containing compounds are widely used as topical and systemic antifungal agents.…”

“…Such a structural design was inspired by our previous results showing that arylsulfonamido 17 arylsulfonato, 18 and (bphenylsulfonyl)ethylthio 8 substituted benzosiloxaboroles (Scheme 1, general structures III, IV, and V, respectively) exhibit high activity against the Gram-positive cocci such as methicillin-sensitive Staphylococcus aureus (MSSA), methicillinresistant S. aureus (MRSA), Enterococcus faecalis and Enterococcus faecium. Based on the presented literature background, [10][11][12][13][14][15][16] we assumed that the introduction of 1,2,3-triazole spacer between arylsulfonyl group and benzosiloxaborole might have further positive impact on the antimicrobial potency.…”