1,2,4-Triazoles: Synthetic approaches and pharmacological importance. (Review)

Abstract

The synthetic routes of 1,2,4-triazole compounds as well as their pharmacological properties have been described. The review focuses intensively on two methods: cycloaddition reaction in the syntheses of various 1,5-dialky-1H-1,2,4-triazole derivatives from the reactive cumulenes with the nitrile precursors as well as the microwave irradiation method.

Flow and Microwave Induced Pellizzari Reactions: Synthesis of Heterocyclic Analogues of the Benzoxazepine Antipsychotic Agents Loxapine and JL-13

“…Given promising preclinical data reported for JL13 [7][8][9], we elected to study the potential of additional heterocyclic variants which might be readily accessible using efficient coupling strategies and which also highlights the benefits of green chemistry approaches [10,11]. Given the functional flexibility of the triazole group and its presence in a number of pharmacologically active molecules [12], we sought to investigate use of the Pellizzari method [13], which relies on one pot coupling, and closure of imino chlorides with substituted hydrazides.…”

Synthesis and evaluation of novel 2-[(1,2,4-triazol-3-yl)thio]acetamide derivatives as potential serum paraoxonase-1 (PON1) activators

“…Triazole derivatives have also capacity of hydrogen bonding which provides binding to biomolecular structures [33,34]. On the other hand, thiazoles/benzothiazoles are another important class of heterocylic compounds found in many bioactive molecules and they have been reported in a large number of literature with a wide scale of biological activities [35,36].…”

Synthesis and Biological Activities of 3-Alkyl-5-substituted 1,2,4-Triazole Derivatives

“…1,2,4,-Triazole and its derivatives are an important class of nitrogenous heterocyclic compounds which has been shown to possess a wide range of pharmacological properties such as antifungal 2,3 , antibacterial 4,5 , antimalarial 6 , antiinflammatory, anticonvulsant, antidepressant, antiviral and antitumor activities [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . Therefore, 1,2,4-triazole derivatives have attracted considerable attention during the last few decades [22][23][24][25] . In the present work we have synthesized some novel alkyl substituted derivatives of 1,2,4-triazole and evaluated their antimicrobial activities.…”