1,2-Diboranes with strong donor substitutes: Synthesis, ovicidal and larvicidal effect on important vector species

Bursalı, Fatma; Şahin, Yüksel; Aygün, Muhittin; Sevincek, Resul; Bıyık, H. Halil; Özgener, Hüseyin; Gürbüz, Burçin

doi:10.1016/j.inoche.2024.112268

Cited by 3 publications

References 39 publications

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Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

Touray,

Ulug,

Gulsen

et al. 2024

Pest Management Science

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BACKGROUNDIn the perpetual struggle to manage mosquito populations, there has been increasing demand for the development of biopesticides to supplant/complement current products. The insecticidal potential of Xenorhabdus and Photorhabdus has long been recognized and is of interest for the control of important mosquitoes like Aedes albopictus which vectors over 20 different arboviruses of global public health concern.RESULTSThe larvicidal effects of cell‐free supernatants, cell growth cultures and cell mass of an extensive list of Xenorhabdus and Photorhabdus spp. was investigated. They were quite effective against Ae. albopictus causing larval mortality ranging between 52–100%. Three Photorhabdus spp. and 13 Xenorhabdus spp. release larvicidal compounds in cell‐free supernatants. Cell growth culture of all tested species exhibited larvicidal activity, except for Xenorhabdus sp. TS4. Twenty‐one Xenorhabdus and Photorhabdus bacterial cells (pellet) exhibited oral toxicity (59–91%) against exposed larvae. The effect of bacterial supernatants on the mosquito eggs were also assessed. Bacterial supernatants inhibited the hatching of mosquito eggs; when unhatched eggs were transferred to clean water, they all hatched. Using the easyPACId approach, the larvicidal compounds in bacterial supernatant were identified as fabclavine from X. szentirmaii and xencoumacin from X. nematophila (causing 98 and 70% mortality, respectively, after 48 h). Xenorhabdus cabanillasii and X. hominickii fabclavines were as effective as commercial Bacillus thuringiensis subsp. israelensis and spinosad products within 5 days post‐application (dpa).CONCLUSIONFabclavine and xenocoumacin can be developed into novel biolarvicides, can be used as a model to synthesize other compounds or/and can be combined with other commercial biolarvicides.This article is protected by copyright. All rights reserved.

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Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

Touray,

Ulug,

Gulsen

et al. 2024

Pest Management Science

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A 3D printed device for vibration-assisted separation of different-stage mosquito larvae

Bursali,

Yetiskin,

Ozcelik

2024

Instrumentation Science & Technology

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Larvicidal and Cytotoxic Activities of Exopolysaccharides Produced by Thermophilic Bacteria

AYTAR,

Bingül,

Touray

et al. 2024

Preprint

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EPSs synthesized by thermophilic bacteria are natural biopolymers that have recently garnered attention due to their potential applications in areas such as pharmaceuticals and biomedicine. In this study, EPSs produced by five distinct thermophilic bacterial isolates from hot springs in Turkey were purified using ion exchange and gel chromatography, and the larvicidal and cytotoxic effects of these EPSs were examined. While Geobacillus thermodenitrificans HBB111 produces the highest quantity (650,9 µg/mL) of EPS, the protein content of crude EPS samples ranges from 0.3–1.5%. EPS111 and EPS261 showed the most effective larvicidal action, eliminating 72% and 62.7% of Ae. albopictus larvae after 48 hours, respectively. Among the purified samples, EPS111 exhibited the most significant effect on the proliferation of PC3 cells, resulting in a 68% inhibition (IC50 of 0,23 mg/mL) followed by EPS106 in a 55% (IC50 of 0,45 mg/mL). According to the results of our study, thermophilic EPSs demonstrate potential due to their insecticidal and anticancer properties.

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1,2-Diboranes with strong donor substitutes: Synthesis, ovicidal and larvicidal effect on important vector species

Cited by 3 publications

References 39 publications

Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

Natural products from Xenorhabdus and Photorhabdus show promise as biolarvicides against Aedes albopictus

A 3D printed device for vibration-assisted separation of different-stage mosquito larvae

Larvicidal and Cytotoxic Activities of Exopolysaccharides Produced by Thermophilic Bacteria

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