1,2-Dihydropyridine derivatives as potential antiulcer agents

Domány, György; Matuz, J.; Sághy, Katalin; Ezer, E.

doi:10.1016/0223-5234(93)90094-u

Cited by 7 publications

(2 citation statements)

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“…Some 1,2-dihydropyridine derivatives have been disclosed as potential anticancer 8 and anti ulcer agents. 9 Despite their potential biological and synthetic utility, methodologies to 1,2-or 1,6-dihydropyridines remain underdeveloped 10 as compared to their 1,4regioisomers, primarily because of the more challenging regioselectivity. Yoshikai et al developed a Ni-catalyzed [2+2+2]-cycloaddition between imines bearing a N-pyridyl group and alkynes to afford 1,2-dihydropyridines.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)

et al. 2018

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A zinc(ii) triflate catalyzed three component synthesis of 1,6-dihydropyridines, involving aldimines, alkynes and electron-deficient dimethyl acetylenedicarboxylate (DMAD), in good to excellent yields has been described. Besides a range of different N-substituents, a variety of both aromatic and aliphatic alkynes could be used. The application of electron-deficient propiolates instead of DMAD resulted in regiospecific incorporation of the ester functionality on the 1,6-dihydropyridine ring. The reaction proceeds via a cascade reaction involving nucleophilic addition of the metal acetylide to the imine, followed by the addition of the intermediately formed propargylic amine to the electron-deficient alkyne and subsequent 6-endo dig cyclization.

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Section: Introductionmentioning

confidence: 99%

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)

et al. 2018

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“…Dihydropyridines (DHPs), an aza‐heterocyclic compounds, play pivotal role in organic chemistry while 1,2‐DHPs are structural motif in various natural products and act as key intermediates for the biosynthesis of indole alkaloids . In facrt, some 1,2‐DHP derivatives have been reported as potential anti‐cancer and antiulcer agents . More recently, these compounds are explored as potential fluorescent probes for biological applications .…”

Section: Introductionmentioning

confidence: 99%

A One‐pot Facile Construction of 1H‐1,2,3‐Triazolyl 1,2‐Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

Rajkumar

Murthy²,

Zehra

et al. 2018

ChemistrySelect

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A one‐pot, facile method has been established for the preparation of 1H‐1,2,3‐triazolyl 1,2‐dihydropyridyl derivatives 6 a‐y. The ring opening of the chromone and cyclo addition are the notable reactions to achieve the target compounds 6 a‐y. All the compounds were screened for their antiproliferative, free radical scavenging (DPPH, ABTS.+), α‐glucosidase inhibitory and anti‐inflammatory activities. The bioactivity profile revealed that the compounds 6 x‐y were shown potent antiproliferative activity against HeLa cell line, while compounds 6 e‐h and 6 w identified as potent ABTS+. and 6 n identified as potent DPPH free radical scavenger. Compounds 6 h‐i, 6 p‐r, 6 u and 6 w denoted promising anti‐inflammatory activity.

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ChemInform Abstract: 1,2‐Dihydropyridine Derivatives as Potential Antiulcer Agents.

et al. 1993

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1,2-Dihydropyridine derivatives as potential antiulcer agents

Cited by 7 publications

References 4 publications

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)

A One‐pot Facile Construction of 1H‐1,2,3‐Triazolyl 1,2‐Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

ChemInform Abstract: 1,2‐Dihydropyridine Derivatives as Potential Antiulcer Agents.

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1,2-Dihydropyridine derivatives as potential antiulcer agents

Cited by 7 publications

References 4 publications

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)2-catalyzed three-component cascade reaction of aldimines and two alkynes (IA2-coupling)

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)2-catalyzed three-component cascade reaction of aldimines and two alkynes (IA2-coupling)

A One‐pot Facile Construction of 1H‐1,2,3‐Triazolyl 1,2‐Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

ChemInform Abstract: 1,2‐Dihydropyridine Derivatives as Potential Antiulcer Agents.

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Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)

Synthesis of highly functionalized 1,6-dihydropyridines via the Zn(OTf)₂-catalyzed three-component cascade reaction of aldimines and two alkynes (IA²-coupling)