“…The 4-anilinoquinazolines 4 host a N , N ′-disubstituted benzamidine motif within their structures, cyclization of which affords the desired benzo[4,5]imidazo[1,2- c ]quinazolines. The literature on the preparation of benzo- or hetareno-fused imidazoles from amidines via oxidative C–N coupling highlighted the use of electro-oxidation and the use of a variety of oxidants including H 2 O 2 , cerium ammonium nitrate (CAN), NaOCl, NCS, MnO 2 , Pb(OAc) 4 , , and hypervalent iodine(III) reagents . In our hands, cyclization efforts using either H 2 O 2 , CAN, NCS, MnO 2 , or Pb(OAc) 4 failed but succeeded with hypervalent iodine(III) reagents.…”