1,2-Naphthoquinone-4-sulfonic acid sodium salt as a reagent for spectrophotometric determination of rimantadine and memantine

Muszalska, Izabela; Sobczak, Agnieszka; Kiaszewicz, I.; Rabiega, K.; Lesniewska, Monika A; Jelińska, Anna

doi:10.1134/s1061934815030120

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Analytical methods for assays of memantine, amantadine, and rimantadine are available in pharmacopeias (e.g. The United States Pharmacopeia (USP) and British Pharmacopoeias (BP) ) and the literature . Most methods avoid the use of optical detection (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…The USP and BP recommend GC with flame ionization detection for the assay of these drugs in API and pharmaceutical products. Moreover, several methods have been proposed for the analysis of memantine in pharmaceutical formulations and biological fluids, such as spectrophotometry and spectrofluorometry , GC–MS , HPLC–MS and HPLC with UV‐Visible and fluorescence detection . In cases of UV or fluorescence detection, derivatization procedures are required to enable their detection.…”

Section: Introductionmentioning

confidence: 99%

“…1) with various pharmacological properties. Memantine (3,5-dimethyl-tricyclo [3,3,1,13,7]decane-1-amine) is a potent neuroprotective agent, which is recommended for treatment of Alzheimer's disease [1]. The mechanism of action has been proposed by blocking N-methyl-D-aspartate receptor [1].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of action has been proposed by blocking N-methyl-D-aspartate receptor [1]. Amantadine (1-aminotricyclo [3,3,1,13,7]decane) and rimantadine (α-methyltricyclo [3,3,1,13,7]decane-1-methylamine) are structurally related derivatives with similar biological properties. Both effectively suppress viral adsorption [2] and are used, in combination with oseltamivir, for prophylaxis Abbreviations: API, active pharmaceutical ingredients; Arg, l-arginine hydrochloride; BP, British Pharmacopoeia; BPM, brompheniramine; CD, cyclodextrin; TR, transfer ratio; USP, The United States Pharmacopeia Conflicts of interest: The authors have declared no conflicts of interest.…”

Section: Introductionmentioning

confidence: 99%

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Brompheniramine as a novel probe for indirect UV detection and its application for the capillary electrophoresis of adamantane drugs

et al. 2017

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Brompheniramine, an antihistamine drug, was employed as a novel UV probe for capillary electrophoresis with indirect UV detection of adamantane drugs (memantine, amantadine, and rimantadine). The probe possesses high molar absorptivity of 24 × 10 L/mol cm at 6 mM, which enables the measurement of these nonchromophore analytes without derivatization. The simple background electrolyte (10 mM sodium dihydrogen phosphate (pH 5.0) containing 5 mM brompheniramine and 6 mM β-cyclodextrin) provided the separation of the analytes in a short time (7.5 min). Under these conditions, brompheniramine had similar mobility to that of the analyte ions resulting in symmetric peaks with minimal electrodispersion. The analytes displace the probe at a one-to-one ratio with transfer values close to unity. β-Cyclodextrin played a role in the resolution of the structurally similar adamantane derivatives. Method validation showed good linearity (r > 0.98), precision (%RSD ≤ 3.30), and accuracy (recoveries ranging from 98 to 109%). The proposed method was successfully applied to determine the adamantane content in pharmaceutical products.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brompheniramine as a novel probe for indirect UV detection and its application for the capillary electrophoresis of adamantane drugs

et al. 2017

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“…New separation method for tricyclic antiviral drugs was developed 4 . Previous works included determination of RMT using IR Analysis 5 , online post column DRT 6 , fluorescent probe 7 , UV-visible spectrophotometry 8 , UHPLC coupled with orbitrap mass spectrometry 9 , use of AQSC for RMT analysis 10 , and simultaneous analysis using tandem mass spectrometry 11 . The present work focused on RP-HPLC method development 12 and its validation 13 .…”

Section: Introductionmentioning

confidence: 99%

"Development and Validation of a Rp-HPLC Method for the Analysis of Rimantadine Hydrochloride in Medicinal Form"

2018

RJC

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The aim of the research work was to conduct precolumn derivatization of Rimantadine hydrochloride (RMT) with Anthraquinone -2 -sulphonyl chloride (AQSC) to develop a validated, selective, precise and accurate RP-HPLC -UV method for the analysis of RMT -AQSC derivative in its Medicinal form. The isocratic mobile phase for the C -18 column consisted of Ethylnitrile and 0.005M 1 -octane sulfonic acid sodium salt monohydrate buffer (pH adjusted to 6.7) in 60:40 volume ratio. Flow rate maintained at one millilitre in one minute at ambient temperature. The ideal UV detection wavelength for RMT derivative was 259 nm. The retention time for both API and the medicine was 6.79 minutes. Linearity was satisfied over a range of 50 ppm to 250 ppm with a correlation coefficient (r) value 0.999. Percentage RSD for precision, accuracy and robustness were less than 2. The LOD and LOQ were 1.32 ppm and 4.0 ppm respectively. Validation was done as per 1CH guidelines and all the results were with in the limits.

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In‐capillary derivatization with fluorescamine for the rapid determination of adamantane drugs by capillary electrophoresis with UV detection

Prapatpong

Nuchtavorn

Macka

et al. 2018

J of Separation Science

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In-capillary derivatization using fluorescamine as the labeling reagent was proposed to enhance the detectability of adamantine drugs (memantine, amantadine and rimantadine) by spectrophotometric detection. Fluorescamine and the drugs were delivered to the capillary electrophoresis instrument at a ratio of 10:1 by zone injection. The derivatization reaction occurred following the application of voltage (20 kV). The derivatized products, hydrolyzed- fluorescamine and excess fluorescamine were separated in 7 min using 100 mM borate buffer (pH 10.0) containing 0.1% w/v of Brij®-35 and 20% v/v of acetonitrile. Validation data showed good linearity (r > 0.98), precision (%RSDs < 3.4), and accuracy (recoveries ranging from 98.0 to 102.0%). The detection and quantitation limits are in the range of 6.0-8.5 and 18-25 μM, respectively. The validation data is comparable to reported methods, however, the current method offers better precision with enhanced sensitivity (up to six times). Applications of the method show percent labeled amounts found in the studied samples within 100.6-109.3%, which complied with the United States Pharmacopeia limit (90.0-110.0%). The method was simple, rapid and, automated, which required no extra instrumentation or skillful operators.

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1,2-Naphthoquinone-4-sulfonic acid sodium salt as a reagent for spectrophotometric determination of rimantadine and memantine

Cited by 7 publications

References 20 publications

Brompheniramine as a novel probe for indirect UV detection and its application for the capillary electrophoresis of adamantane drugs

Brompheniramine as a novel probe for indirect UV detection and its application for the capillary electrophoresis of adamantane drugs

"Development and Validation of a Rp-HPLC Method for the Analysis of Rimantadine Hydrochloride in Medicinal Form"

In‐capillary derivatization with fluorescamine for the rapid determination of adamantane drugs by capillary electrophoresis with UV detection

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