1-(2-Nitrophenyl)-3-phenylthiourea

Abstract

The title compound, C13H11N3O2S, was prepared by reaction of 2-nitro­benzenamine, KOH and 1-isothio­cyanato­benzene in an ethanol solution at room temperature. The dihedral angles formed between the thiourea plane and the phenyl rings are 61.9 and 31.0°. The dihedral angle between the two phenyl rings is 78.1°. In the crystal structure, there are weak inter­molecular N—H⋯S and C—H⋯S hydrogen-bonding inter­actions.

Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-tumor Agents

“…To facilitate the synthetic pathways, we prepared the guanidine derivatives 5a,b by reaction of isothiurinium HCl with sulfadimidine and 1-(4-aminophenyl)-3-phenylthiourea, which were prepared by the reaction of 4-nitroaniline with phenylisothiocyanate [ 21 ] followed by the reduction of the thiourea derivative with zinc and ammonium formate in ethanol at reflux. The base was obtained by trituration with NaHCO 3 solution ( Scheme 2 ).…”