1–2 ​T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis

Zhang, Gejing; Zhen, Chenxiao; Yang, Juhua; Zhang, Zheyuan; You-de, WU; Che, Jingmin; Shang, Peng

doi:10.1016/j.jot.2022.10.007

Cited by 13 publications

(9 citation statements)

References 37 publications

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“… 14 Furthermore, Zhang et al found that after placing Raw264.7 cells in 1–2 T SMFs for 4 days, the osteoclast formation in the presence of Ferumoxytol was reduced. 15 Kotani et al also found that 8 T high SMF can align both mouse osteoblastic MC3T3-E1 cells and the orientation of bone formation. 16,17 …”

Section: Bone Regenerationmentioning

confidence: 95%

Static magnetic fields in regenerative medicine

Xie,

Song,

Guo

et al. 2024

APL Bioengineering

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All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine. Most reports in the literature focus on the influence of SMF on bone regeneration, wound healing, and stem cell production. Multiple aspects of the cellular events, including gene expression, cell signaling pathways, reactive oxygen species, inflammation, and cytoskeleton, have been shown to be affected by SMFs. Although no consensus yet, current evidence indicates that moderate and high SMFs could serve as a promising physical tool to promote bone regeneration, wound healing, neural differentiation, and dental regeneration. All in vivo studies of SMFs on bone regeneration and wound healing have shown beneficial effects, which unravel the great potential of SMFs in these aspects. More mechanistic studies, magnetic field parameter optimization, and clinical investigations on human bodies will be imperative for the successful clinical applications of SMFs in regenerative medicine.

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Section: Bone Regenerationmentioning

confidence: 95%

Static magnetic fields in regenerative medicine

Xie,

Song,

Guo

et al. 2024

APL Bioengineering

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“…And the osteoclast differentiation was suppressed by decreasing the levels of ROS and blocking NF-κB and MAPK signaling pathways. 159 Chen et al 160 designed a novel nano-fluorescent carbon quantum dots (N-CDs), the results showed the osteoclastogenesis and bone resorption was attenuated via downregulating ROS level by impaired the activation of NF-κB and MAPK pathways. Therefore, NPs can inhibit osteoclast differentiation via the inhibition of MAPK and NF-κB signaling pathways, and decrease the levels of ROS ( Fig.…”

Section: Research Progress On the Interaction Of Nanoparticles With B...mentioning

confidence: 99%

Recent advances of nanoparticles on bone tissue engineering and bone cells

Zhang,

Zhen,

Yang

et al. 2024

Nanoscale Adv.

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“…Notably, iron oxide nanoparticles (IONs), such as ferumoxytol, approved for iron supplementation in CKD anemia patients will bring additional benefits to anemia patients [ 167 ]. For example, ferumoxytol has been shown to be used in the treatment of other diseases, including leukemia and osteoporosis [ 168 , 169 , 170 ]. Therefore, IONs are expected to be the most promising drugs for the treatment of iron deficiency complicated by osteoporosis.…”

Section: Prevention Of Iron Deficiencymentioning

confidence: 99%

Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss

Yang

Feng

et al. 2023

IJMS

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Iron is one of the essential mineral elements for the human body and this nutrient deficiency is a worldwide public health problem. Iron is essential in oxygen transport, participates in many enzyme systems in the body, and is an important trace element in maintaining basic cellular life activities. Iron also plays an important role in collagen synthesis and vitamin D metabolism. Therefore, decrease in intracellular iron can lead to disturbance in the activity and function of osteoblasts and osteoclasts, resulting in imbalance in bone homeostasis and ultimately bone loss. Indeed, iron deficiency, with or without anemia, leads to osteopenia or osteoporosis, which has been revealed by numerous clinical observations and animal studies. This review presents current knowledge on iron metabolism under iron deficiency states and the diagnosis and prevention of iron deficiency and iron deficiency anemia (IDA). With emphasis, studies related to iron deficiency and bone loss are discussed, and the potential mechanisms of iron deficiency leading to bone loss are analyzed. Finally, several measures to promote complete recovery and prevention of iron deficiency are listed to improve quality of life, including bone health.

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1–2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis

Cited by 13 publications

References 37 publications

Static magnetic fields in regenerative medicine

Static magnetic fields in regenerative medicine

Recent advances of nanoparticles on bone tissue engineering and bone cells

Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss

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1–2 ​T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis

Cited by 13 publications

References 37 publications

Static magnetic fields in regenerative medicine

Static magnetic fields in regenerative medicine

Recent advances of nanoparticles on bone tissue engineering and bone cells

Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss

Contact Info

Product

Resources

About

1–2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis