1,25-dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade

1, 25(OH)2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

“…It seems that mTOR is a target for the immunomodulatory effects of vitamin D 32 . 1, 25-Dihydroxyvitamin D3-3-bromoacetate, a vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade 33 Thus, the present study intends to verify our hypothesis that 1, 25(OH) 2 D 3 treatment can inhibit β cell apoptosis induced by hyperglycemia, and the therapy works by suppressing mTOR.…”

Vitamin D cell signalling in health and disease

“…Similarly, Vitamin D also can reduce the activity of the PI3K/Akt/mTOR components of this pathway [114]. For example, a Vitamin D analog 1,25-dihydroxyvitamin D 3 -3-bromoacetate (BE) exerts a marked immunosuppressive effect on T cells taken from patients with psoriasis or rheumatoid arthritis (RA) by decreasing the phosphorylation of both Akt and mTOR [115]. This inhibitory activity of Vitamin D depends on two mechanisms.…”

1α,25-Dihydroxyvitamin D3 upregulates HIF-1 and TREM-1 via mTOR signaling

“…In previous study, we showed that 1,25(OH) 2 D 3 strongly upregulates the expression of TREM-1 in human monocytes/macrophages and TREM-1 stimulation enhances the expression of proinflammatory cytokines in 1,25(OH) 2 D 3 -treated cells, suggesting that 1,25(OH) 2 D 3 may function as an enhancer of the innate immune response by upregulating TREM-1 expression, in addition to inducing the antimicrobial peptide cathelicidin [3]. Vitamin D 3 was previously reported to inhibit mTOR signaling in various types of cells including T cells, osteoblasts, and MCF-7 cells [27][28][29]. In contrast to previous reports, we showed that the 1,25(OH) 2 D 3 depends on mTOR signaling to induce TREM-1 and HIF-1 expression in human macrophages.…”