1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Pourgholami, Mohammad H.; Morris, David L.

doi:10.1016/j.jsbmb.2004.03.065

Cited by 15 publications

(6 citation statements)

References 38 publications

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“…Huang et al [49] demonstrated that VDR gene polymorphisms at BsmI, ApaI, and TaqI were associated with distinct clinical phenotypes of hepatitis B carriers in Taiwanese patients but not with the risk of HCC suggesting a limited role of VDR gene polymorphisms in hepatocarcinogenesis [49]. However, a biochemical evidence clearly indicated that HCC cells respond to the inhibitory effect of vitamin D and its analogs [50]. Moreover, it had been reported that the antiproliferative effects of vitamin D against HCC cells correlate with intracellular VDR level [44,51].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

Mohammed¹

2017

GHOA

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Background: Vitamin D has emerging roles in fibrogenesis, cell cycle arrest, immune modulation, and tumorigenesis. Several single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are associated with tumorigenesis in various organs.Objective: to investigate the association between the VDR gene polymorphisms and Hepatocellular carcinoma (HCC) risk and severity in Egyptian patients with chronic hepatitis C (CHC). Methods:Five hundred thirty outpatients with chronic hepatitis C virus (HCV) infection were initially enrolled, of which 180 patients with CHC, 180 patients with liver cirrhosis and 170 patients with HCC. Another 170 age-and sex-matched healthy controls were enrolled. Genotyping of VDR gene at BsmI, ApaI and TaqI loci was performed. Evaluation of clinicopathological features of HCC was done. Data were analyzed using SPSS software (Version 17.0). Results Conclusion:The present study provided significant associations of VDR gene SNPs (ApaI CC genotype and bAt[CCA]-haplotype) with HCC development and disease severity in HCV-infected Egyptian patients. Thus, the determination of these VDR genetic variants in HCV patients could help identification of patients at-risk of HCC development.

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Section: Discussionmentioning

confidence: 99%

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

Mohammed¹

2017

GHOA

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“…A VDR-és CYP27B1-expresszió mértéke hepatocellularis carcinomaszövetben és a tumorparaméterek közötti összefüggés [17,27]. Mindezek alapján célszerűnek látszik az egyes hepatocellularis carcinomás betegek között lévő klinikopatológiai különbségek vizsgálata és ezek szerepének elemzése az 1,25-dihidroxi-D 3 -vitamin-kezelésre adott válaszban.…”

Section: Táblázatunclassified

A D-vitamin metabolizmusa humán hepatocellularis carcinomában és az azt körülvevő tumormentes májszövetben

et al. 2016

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Bevezetés: Az 1,25-dihidroxi-D 3 -vitamin tumorellenes hatása hepatocellularis carcinomában már részben ismert. Cél-kitűzés: Az 1,25-dihidroxi-D 3 -vitamint inaktiváló CYP24A1-mRNS-és fehérjeexpresszió, az aktiváló CYP27B1-és a VDR-mRNS-expresszió mértékének összehasonlítása humán hepatocellularis carcinomában és az azt körülvevő tumormentes májszövetben. Módszer: 13 beteg friss fagyasztott májszövetmintáját a CYP24A1-mRNS-és fehérje-, 36 beteg paraffinba ágyazott májszövetmintáját használtuk a VDR-és a CYP27B1-mRNS-expresszió kimutatására. Az mRNS-expressziót RT-PCR-rel, a fehérjét immunhisztokémiai vizsgálatokkal mértük. Eredmények: A hepatocellularis carcinomaminták többségében kimutatható volt a CYP24A1-mRNS-expresszió, míg a nem tumoros májszö-vetminták egyikében sem. A CYP27B1-és VDR-expresszió szignifikánsan alacsonyabb hepatocellularis carcinomában a tumormentes májszövethez képest (p<0,05). A CYP24A1-mRNS-expressziót fehérjeszintézis követi. Következteté-sek: A CYP24A1 inaktiváló enzim jelenléte, az aktiváló CYP27B1 és a VDR csökkent expressziója humán hepatocellularis carcinomában a D-vitamin csökkent helyi aktivitására enged következtetni, mint egy menekülő mechanizmus a tumor részéről a D-vitamin antitumorhatása ellen. Orv. Hetil., 2016, 157(48), 1910-1918. Kulcsszavak: hepatocellularis carcinoma, CYP24A1, CYP27B1, D-vitamin Vitamin D metabolism and signaling in human hepatocellular carcinoma and surrounding non-tumorous liverIntroduction: 1,25-Dihydroxy vitamin D 3 mediates antitumor effects in hepatocellular carcinoma. Aim: We examined mRNA and protein expression differences in 1,25-Dihydroxy vitamin D 3 -inactivating CYP24A1, mRNA of activating CYP27B1 enzymes, and that of VDR between human hepatocellular carcinoma and surrounding non-tumorous liver. Methods: Snap-frozen tissues from 13 patients were studied for mRNA and protein expression of CYP24A1. Paraffin-embedded tissues from 36 patients were used to study mRNA of VDR and CYP27B1. mRNA expression was measured by RT-PCR, CYP24A1 protein was detected by immunohistochemistry. Results: Expression of VDR and CYP27B1 was significantly lower in hepatocellular carcinoma compared with non-tumorous liver (p<0.05). The majority of the HCC samples expressed CYP24A1 mRNA, but neither of the non-tumorous liver. The gene activation was followed by CYP24A1 protein synthesis. Conclusions: The presence of CYP24A1 mRNA and the reduced expression of VDR and CYP27B1 mRNA in human hepatocellular carcinoma samples indicate decreased bioavailability of 1,25-Dihydroxy vitamin D 3 , providing an escape mechanism from the anti-tumor effect.

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“…However, the antiproliferative effects of active form of vitamin D against HCC cell had been reported to correlate with intracellular VDR level. 38 A vitamin D analog, Seocalcitol, had been used to treat patients with inoperable HCC. 39 Nevertheless, no further controlled studies have been carried out.…”

Section: Vitamin D Receptor Polymorphisms and Hepatitis Bmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan

et al. 2009

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Vitamin D exhibits immunomodulatory and antiproliferative effects through vitamin D receptor (VDR) in chronic infections and cancers. We genotyped the BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) polymorphisms of VDR gene in 250 Taiwanese chronic hepatitis B virus (HBV) carriers who were categorized into six phenotypes. After adjustment for age and sex, the frequencies of the VDR B/b, B/a, B/T, B/a/T in patients with hepatitis flare(s) were lower than those without (7 vs 20%, P ¼ 0.009; 1 vs 9%, P ¼ 0.004; 3 vs 10%, P ¼ 0.007; 1 vs 9%, P ¼ 0.005, respectively); in contrast, T/t, A/T, A/t, b/A/t were higher in flare(s) (8 vs 3%, P ¼ 0.003; 49 vs 34%, P ¼ 0.027; 2 vs 1%, P ¼ 0.004; 0.5 vs 0%, P ¼ 0.001, respectively).

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1,25-Dihydroxyvitamin D3 in lipiodol for the treatment of hepatocellular carcinoma: cellular, animal and clinical studies

Cited by 15 publications

References 38 publications

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

The Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus

A D-vitamin metabolizmusa humán hepatocellularis carcinomában és az azt körülvevő tumormentes májszövetben

Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan

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