1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

Ferreira, Gabriela B; Gysemans, Conny; Demengeot, Jocelyne; Cunha, João Paulo Monteiro Carvalho Móri da; Vanherwegen, An-Sofie; Overbergh, Lut; Belle, Tom Van; Pauwels, Femke; Verstuyf, Annemieke; Korf, Hannelie; Mathieu, Chantal

doi:10.4049/jimmunol.1302350

Cited by 114 publications

(91 citation statements)

References 54 publications

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“…The lipophilic drug, 1,25-dihydroxyvitamin D3 (calcitriol), inhibits NF-κB and induces a tolerogenic phenotype when incubated with human or mouse DCs in vitro [30,31]. We constructed (Fig.…”

Section: Curcumin Liposome or Calcitriol Liposome Treatment Improves mentioning

confidence: 99%

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

et al. 2018

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, Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis, Metabolism (2017Metabolism ( ), doi: 10.1016Metabolism ( /j.metabol.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ConclusionsLiposomes are a new strategy to target lipid rich inflammatory dendritic cells and have potential to deliver immunomodulatory compounds to treat NASH.

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Section: Curcumin Liposome or Calcitriol Liposome Treatment Improves mentioning

confidence: 99%

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

et al. 2018

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“…The possibility that anergic T cells can also acquire suppressive capacities supports their fundamental role in the control of immune responses. Thus, T cell anergy is an effective mechanism to eradicate aberrant T cell responses to "self" and for the reestablishment of self-tolerance in patients with autoimmune diseases [159,160].…”

Section: T Cell Anergymentioning

confidence: 99%

Physiology and Pathology of Immune Dysregulation: Regulatory T Cells and Anergy

Torres¹,

López-Casado²,

León³

et al. 2017

Physiology and Pathology of Immunology

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The immune system is responsible for the defense of the organism. It controls what is introduced into it and identifies it as self from non-self. The defensive mechanisms activated by the immune system are directed against pathological microbes and toxic or allergenic proteins, and it must avoid responses that produce excessive damage of self-tissues, inducing tolerance to avoid autoimmunity and other immunopathologies. Regulatory Tcells play an essential role in these active processes, using several distinct suppressive mechanisms. The immune dysregulatory diseases result from defects affecting regulatory T cell development and/or function, including the impact of essential genes mutations for Tregulatory cell functions and the associated autoimmune syndromes.

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“…Human and murine immature DCs (iDC) were prepared according to previously described protocols (26,27). The protocol for coincubation of cancer cells with iDCs has been previously described (28,29).…”

Section: Dc-maturation Analysismentioning

confidence: 99%

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

et al. 2015

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Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that can incite protective antitumor immunity. In this study, we investigated whether locoregionally applied therapies, such as melphalan, used in limb perfusion for melanoma (Mel-ILP) produce related immunogenic effects. In human melanoma biopsies, Mel-ILP treatment upregulated IL1B, IL8, and IL6 associated with their release in patients' locoregional sera. Although induction of apoptosis in melanoma cells by melphalan in vitro did not elicit threshold levels of endoplasmic reticulum and reactive oxygen species stress associated with danger signals, such as induction of cell-surface calreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan administration in vivo could stimulate a CD8 þ T cell-dependent protective antitumor response. Interestingly, the vaccination effect was potentiated in combination with exogenous calreticulin, but not tumor necrosis factor, a cytokine often combined with Mel-ILP. Our results illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators such as the danger signal calreticulin. Cancer Res; 75(8);

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1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

Cited by 114 publications

References 54 publications

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

Physiology and Pathology of Immune Dysregulation: Regulatory T Cells and Anergy

Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface–Associated Calreticulin

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