1-[3,5-Bis(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Abstract

In the asymmetric unit of the title compound, C17H14F2N2O, there are three independent mol­ecules (A, B and C) which differ slightly in the relative orientations of the two fluoro­phenyl rings. In mol­ecules A and C one of the fluoro­phenyl rings is disordered over two positions, with occupancy ratios of 0.72 (2):0.28 (2) for mol­ecule A and 0.67 (2):0.33 (2) for mol­ecule C. The dihedral angle between the two fluoro­phenyl rings in the independent mol­ecules lie in the range 70.3 (3)–84.0 (3)°. In the crystal structure, the mol­ecules are linked via inter­molecular C—H⋯O and C—H⋯F hydrogen bonds and π⋯π stacking inter­actions [centroid–centroid distance = 3.7508 (13) Å], forming a three-dimensional network.

Crystal structure of (2E)-3-(4-benzyloxyphenyl)-1-(4,4’’-difluoro-5’- methoxy-1,1’:3’,1’’-terphenyl-4’-yl)prop-2-en-1-one, C35H26F2O3

“…Chalconesare highly reactive substances of varied nature. They have been reported to possess many interesting pharmacological activities [2] including anti-inflammatory, antimicrobial, antifungal, antioxidant, cytotoxic, antitumor and anticancer activities [3,4].Inview of the pharmacological importance of terphenyls and chalcones and in continuation of our work on the synthesis of various derivatives of 4,4'-difluoro chalcone [5][6][7][8] we herein report the crystal and molecular structure of the title compound. The C=C double bond shows (E)-configuration.…”

Crystal structure of (2E)-3-(biphenyl-4-yl)-1-(4,4’’-difluoro-5’-methoxy- 1,1’:3’,1’’-terphenyl-4’-yl)prop-2-en-1-one, C34H24F2O2

“…being potent anticoagulants, immuno-suppressants, antithrombotics, neuroprotectives, specific 5-lipoxygenase inhibitors) and showing cytotoxic activities [4]. In view of the pharmacological importance of terphenyls and chalcones, and in continuation of our work on synthesis of various derivatives of 4,4'-difluoro chalcone [5][6][7][8], the molecular and crystal structure of the title compound is reported. The C=C double of the Michael system is (E)-configured.…”

(2E)-3-(6-Methoxynaphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one and its cyclocondensation product with guanidine, (4RS)-2-amino-4-(6-methoxynaphthalen-2-yl)-6-(pyridin-3-yl)-3,4-dihydropyrimidine monohydrate: two types of hydrogen-bonded sheet

“…Thus, for example, the cyclocondensation reactions of chalcones with simple hydrazines lead to the formation of dihydropyrazole derivatives (Fun et al, 2010;Jasinski, Guild et al, 2010;Jasinski, Pek et al, 2010;Samshuddin et al, 2010). Following these precedents, we have now prepared the title dihydropyrimidine derivative (4RS)-2-amino-4-(6-methoxynaphthalen-2-yl)-6-(pyridin-3-yl)-3,4-dihydropyrimidine monohydrate, (II) (Fig.…”