1,3,5-Triaza-7-phosphaadamantane (PTA)

Abstract

The title compound, bis(1,2-diphenyl-2-sulfanylideneethanethiolato-2 S,S 0 )-(1,3,5-triaza-7-phosphaadamantane-P)cobalt(II) dichloromethane hemisolvate, [Co(pdt) 2 (PTA)]Á0.5C 2 H 4 Cl 2 or [Co(C 14 H 10 S 2 ) 2 (C 6 H 12 N 3 P)]Á0.5C 2 H 4 Cl 2 , contains two phenyldithiolene (pdt) ligands and a 1,3,5-triaza-7-phosphaadamantane (PTA) ligand bound to cobalt with the solvent 1,2-dichloroethane molecule located on an inversion center. The cobalt core exhibits an approximately square-pyramidal geometry with partially reduced thienyl radical monoanionic ligands. The supramolecular network is consolidated by hydrogenbonding interactions primarily with nitrogen, sulfur and chlorine atoms, as well as parallel displaced -stacking of the aryl rings. The UV-vis, IR, and CV data are also consistent with monoanionic dithiolene ligands and an overall Co II oxidation state.

Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines

“…In designing our compound library, we employed the phosphines 1,3,5-triaza-7-phosphaadamantane (PTA), tris­(hydroxymethyl)­phosphine (THP), and 1,4-diacetyl-1,3,7-triaza-5-phosphabicylco[3.3.1]­nonane (DAPTA) because these ligands effectively confer water solubility to their coordination complexes. − To further screen for cytotoxic effects of the rhenium photoproducts, we explored five different diimine ligands, 1,10-phenanthroline ( 1 ), 2,9-dimethyl-1,10-phenanthroline ( 2 ), 2,2′-bipyridine ( 3 ), 4,4′-dimethyl-2,2′-dipyridyl ( 4 ), and 4,4′-dimethoxy-2,2′-bipyridine ( 5 ). We hypothesized that this diverse set of compounds would possess a range of photophysical and biological properties, some of which would be valuable for use in PACT.…”

1,3,5‐Triaza‐7‐phosphaadamantane (PTA) Derived Caged Phosphines for Palladium‐Catalyzed Selective Functionalization of Nucleosides and Heteroarenes

“…1,3,5-Triaza-7-phosphaadamantane (PTA) is a versatile caged phosphine ligand obtained from hexamethylenetetraamine (HMTA),which exhibits appreciable water solubility and σdonation capability. [17] Both properties have played a crucial part in the success associated with its employment as a ligand in a wide variety of catalytic processes. PTA attracted the attention of Kapdi and co-workers as a possible solution to the problems associated with the modification of nucleosides in aqueous media that remained unexplored until 2013.…”

7-((5-Bromo-1H-indol-3-yl)(4-methoxyphenyl)methyl)-1,3,5-triaza-7-phosphaadamantan-7-ium Tetrafluoroborate

“…The phosphine-based ligand 1,3,5-triaza-7-phosphaadmantane (PTA), which is also a Lewis base, is frequently used in organometallic chemistry, homogeneous transition metal catalysis, and organocatalytic methods [6]. Because of its three tertiary amine functions, it can be easily incorporated into hydrogen-bonding networks and is easily solvated.…”

“…conditions via PTA-cage cleavage [7]. Furthermore, considering that PTA and its sultanate-derivative salts, PTABS and PTAPS, are highly water soluble, it was anticipated that the resulting PTA-di-aryl-methyl phosphonium salts will be as well [6,[10][11][12]. To initiate a respective study, the synthesis of 7-((5-bromo-1H-indol-3-yl)(4-methoxyphenyl)methyl)-1,3,5-triaza-7-phosphaadamantan-7-ium tetrafluoroborate was investigated, with its synthesis and comprehensive characterization being reported here.…”