1,3,5-Trithianes and sulfur monochloride/sodium sulfide: an alternative route to 3,5-disubstituted 1,2,4-trithiolanes

Abstract

Treatment of substituted 1,3,5-trithianes with S 2 Cl 2 and Na 2 S under mild conditions provides 3,5-disubstituted 1,2,4-trithiolanes, as mixture of diastereoisomers.

Recent Applications of Hexamethyldisilathiane (TMS2S) in Organic Synthesis

“…24 In contrast, the same process applied to alkyl aldehydes provides the corresponding 1,3,5-trithianes. 25 TMS 2 S promotes the cleavage of S–S bond in aromatic disulfides enabling the synthesis of the corresponding alkyl aryl sulfides through reaction of in situ generated thiosilanes with alkyl carboxylates (Table 1 , J). 26 The scope of this reaction has been extended to the synthesis of alkyl aryl selenides from diaryl diselenides.…”