1,3-Bis(2,6-diisopropylphenyl)-2-trichloromethylimidazolidine

Abstract

Abstract:A new chloroform adduct of the N-heterocyclic carbene (NHC) 1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene (SIPr) has been prepared via C-H bond activation of the chloroform at the carbene carbon. This redox product was crystallized and was characterized by 1 H and 13 C-NMR spectroscopy, elemental analysis (EA), and single-crystal X-ray diffraction. The 1 H and 13 C-NMR spectroscopic data are in agreement with the crystal structure. Density functional theory (DFT) calculations were performed as a means for comparison to experimental data and the computational results are in agreement with those obtained experimentally.

Bis(2-cyanoacetamide) in Heterocyclic Synthesis: Synthesis of Some Bis[2-oxopyridine, 2-iminochromene, Chromeno[3,4-c]pyridine, Benzochromeno[3,4-c]pyridine] Derivatives

“…We have worked on a project for the past years that aims to provide new, straightforward methods for synthesizing several new heterocycles of biological importance using inexpensive, readily available starting intermediates in laboratories [1][2][3][4][5][6][7][8][9][10][11][12] . The synthesis of novel mono-and bis-heterocyclic derivatives, which are predicted to display a variety of biological activities, has drawn more interest in recent years [13][14][15][16][17][18][19][20] . The pyridine unit was found in structurally simple pharmaceutical agents like 2-pyridone ligand, isoniazid, milrinone, bupicomide, and SD-560 [21][22][23][24][25][26][27] (Fig.…”