1,3-Dichloro-5,5-dimethylhydantoin as a Novel and Efficient Homogeneous Catalyst in Biginelli Reaction

Abstract

A new and efficient method for the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones via Biginelli synthesis using catalytic amounts of 1,3-dichloro-5,5-dimethylhydantoin is presented. Short reaction times, easy work-up, high yields of products and stability, easy-handling, non-toxicity and cheapness of the catalyst are noteworthy advantages of the present work.

Efficient four‐component synthesis of spiroindole derivatives catalysed by a versatile and reusable nano‐paramagnetic catalyst

“…In continuation of our efforts to develop new, green chemistry methods as well as our interest in applications of heterogeneously catalysed organic reactions, we decided to investigate the possibility of a simple and facile synthesis of spiro(indoline‐3,4‐pyrano[2,3‐ c ]pyrazole) derivatives via a one‐pot four‐component reaction using PFu@ Fe 3 O 4 nanocomposite as catalyst. The PFu@Fe 3 O 4 nanocomposite was synthesized via in situ polymerization at room temperature.…”

Trichloroisocyanuric acid as an efficient homogeneous catalyst for the chemoselective synthesis of 2-substituted oxazolines, imidazolines and thiazolines under solvent-free condition

“…In continuation of our work to recommend new catalysts for organic syntheses, [36][37][38][39][40][41][42] now TCCA as a highly efficient homogeneous catalyst for the preparation of 2-oxazolines, 2-imidazolines and 2-thiazolines from nitriles is presented (Scheme 1).…”

Al(NO3)3 · 9H2O: An Efficient Catalyst for the One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones Both under Reflux or Solvent‐Free Conditions

“…Synthetic strategies for the dihydropyrimidinone nucleus involve both one-pot and multistep approaches [8,9]. At present, several general methods are known for the preparation of dihydropyrimidinones, using various Lewis and protic acids such as BF 3 ⋅OEt 2 [10], ZrCl 4 [11,12], Sc(OTf) 3 [13], zeolites [14][15][16], SbCl 3 [17], CuCl 2 ⋅2H 2 O [18] trichloroisocyanuric acid (TCCA) [19], RuCl 3 [20], silica sulfuric acid (SSA) [21], and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) [22]. However, some of these procedures suffer from disadvantages such as unsatisfactory yields, cumbersome product isolation procedures, and environmental pollution.…”