1,3-Dimethyl-1<i>H</i>-indazol-6-amine

Zhang, Xiaokai; Liu, Bing-Ni; Liu, Mo; Liu, Dengke; Wang, Ping-Bao

doi:10.1107/s1600536812013694

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2019

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“…Regioselective methylation at the 2-position of 3-methyl-6nitro-1H-indazole by refluxing with dimethyl carbonate (DMC) in the presence of triethylenediamine (DABCO) affording 2,3-dimethyl indazole 2 in 81% yield is described. 16 In our hands the repeated experiment resulted in a mixture of 1,3-and 2,3-dimethyl indazoles 2 and 3 (Scheme 2); the same result has been reported in another case 17 when 1,3-dimethyl indazole 3 was isolated in 37% yield.…”

Section: ■ Results and Discussionsupporting

confidence: 84%

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Process-Related Impurities of Pazopanib

Terentjeva

Muceniece

Lusis

2019

Org. Process Res. Dev.

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The main target of this study was to synthesize reference compounds for HPLC analysis of impurities, produced in Pazopanib synthesis. It is highly desirable that impurity standards are made available to help in developing an HPLC control method that could be suitable for use in the industrial process. To the best of our knowledge, most of these impurities are not commercially available and no synthetic methods have been reported. Potential impurities were synthesized, and their structures were established by various spectroscopy techniques.

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Section: ■ Results and Discussionsupporting

confidence: 84%

“…The structure of 1,3-dimethyl-1H-indazol-6-ylamine (base, prepared by catalytic hydrogenation) is confirmed by singlecrystal X-ray study 17 without reporting other characteristics. The substance was characterized only by MS-ESI when it was prepared by reduction with hydrazine hydrate.…”

Section: ■ Results and Discussionmentioning

confidence: 91%