1,3-Dioxole-2-spiro-4'-(3',3'-diethylpyrrolidin-2'-one)

Distinct molecular structures and hydrogen bond patterns of α,α-diethyl-substituted cyclic imide, lactam, and acetamide derivatives in the crystalline phase

“…A comparison of the geometric properties of hydrogen bonds (Table 3) indicated that that H-bonding is somewhat weaker in the dimers of lactam 2. Interestingly, a 3,3-diethylpyrrolidin-2-one derivative with a dioxolane substituent in position 4 has a substantially different molecular packing while retaining the H-bonded dimer motif [10].…”

“…While the solid-state chemistry of -substituted succinimides has been studied extensively (including two recent studies from our groups [8,9]), the same cannot be said about -substituted lactams and acetamides. To the best of our knowledge, only two crystal structures of substituted lactams have been solved: one for 1,3-dioxole-2-spiro-4'-(3',3'-diethylpyrrolidin-2'one) [10] and another for 3-allyl-3-phenylpiperidin-2-one [11] (the latter paper concerns organic 5 synthesis, and no discussion of the crystal structure of 3-allyl-3-phenylpiperidin-2-one was given). Regarding -substituted acetamides, crystal structures of several alkyl-substituted acetamide derivatives have been reported [12][13][14], including our groups' recent report concerning crystal structures and absolute configurations of enantiomers of 2-phenylbutyramide [8].…”