2010
DOI: 10.1016/j.tetasy.2010.03.054
|View full text |Cite
|
Sign up to set email alerts
|

1,3-Dipolar cycloaddition of nitrile oxides to (R)-1-(1-phenylethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: synthesis and antimycobacterial evaluation of novel enantiomerically pure di- and trispiroheterocycles

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
3
0

Year Published

2012
2012
2020
2020

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 25 publications
(3 citation statements)
references
References 31 publications
0
3
0
Order By: Relevance
“…[1][2][3][4][5][6][7] In particular, spiro-and dispiropyrrolidines are important structural entities of many alkaloids and biologically active substances, 8,9 many of which are potential antiviral, anticancer, and anticonvulsant agents. 10,11 5-R-3-arylmethylidene-3H-furan-2-ones may be used as accessible and promising substrates in 1,3-dipolar cycloaddition reactions.…”
mentioning
confidence: 99%
“…[1][2][3][4][5][6][7] In particular, spiro-and dispiropyrrolidines are important structural entities of many alkaloids and biologically active substances, 8,9 many of which are potential antiviral, anticancer, and anticonvulsant agents. 10,11 5-R-3-arylmethylidene-3H-furan-2-ones may be used as accessible and promising substrates in 1,3-dipolar cycloaddition reactions.…”
mentioning
confidence: 99%
“…Depending on the substituted alkenes, the FMO analysis found that the alkenes can behave as electrophiles and nucleophiles. Other reactivity descriptors such as Fukui indexes, local softness and local philicity have also been utilized in predicting the regioselectivity and explain the difference in reactivity of a particular reaction [29][30][31][32][33].…”
Section: Introductionmentioning
confidence: 99%
“…1,3‐Dipolar cycloaddition reaction has been used for the synthesis of five‐membered ring heterocycles. These new ring systems have been one of the most widely used groups of biologically active compounds and were extensively used for the synthesis of important key compounds . There are many dipolar cycloaddition reactions reported in the literature .…”
Section: Introductionmentioning
confidence: 99%