1-[4-(4-Fluorophenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-5-yl]ethanone

Abstract

In the title mol­ecule, C13H13FN2OS, the heterocyclic ring adopts a slightly distorted flattened boat conformation, and the plane through the four coplanar atoms makes a dihedral angle of 87.45 (14)° with the benzene ring. The thione, acetyl and methyl groups lie on the opposite side of the heterocyclic mean plane to the fluorophenyl group, which has an axial orientation. N—H⋯O, N—H⋯S, C—H⋯F and C—H⋯O inter­molecular hydrogen bonds and a weak C—H⋯π inter­action involving the benzene ring are found in the crystal structure.

1-[4-(4-Isopropylphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-5-yl]ethanone

“…For chemical and biological applications and for the closely related crystal structures of the chloro and fluoro derivatives, see: Anuradha et al (2009Anuradha et al ( , 2012.…”

“…As part of our investigations of dihydropyrimidine derivatives (Anuradha et al, 2009(Anuradha et al, , 2012 to compare their chemical and biological activities, we have undertaken the X-ray crystal structure analysis of the title compound.…”