1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor

Wiles, Charlotte; Watts, Paul; Haswell, Stephen J.; Pombo‐Villar, Esteban

doi:10.1039/b202210a

Cited by 48 publications

(36 citation statements)

References 8 publications

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“…Two further examples of organic syntheses in microstructured reactors by Haswell and co-workers employ liquid transport through electroosmosis (Scheme 7), [111] the results of which were heavily dependent on the flow path used. During a continuous operating mode a conversion of only 15 % was achieved.…”

Section: Methodsmentioning

confidence: 98%

“…[80] Fluorination, [34,[89][90][91][92][93] chlorination, [48] nitration, [32,36,[94][95][96][97] hydrogenation, [98][99][100][101] and oxidation [39,40,56,[102][103][104][105][106][107][108][109][110] reactions have been described in numerous examples. The spectrum of chemical conversions includes many known chemical reaction types, such as additions, [56,102,105,106,111] eliminations, [74,99,[112][113][114][115][116] nucleophilic substitutions on aliphatics, [117] electrophilic substitutions on aromatics, [34,91,[94][95][96] cycloadditions, [8...…”

Section: Perspectives For Reactions In Microstructured Reactorsmentioning

confidence: 99%

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Chemistry in Microstructured Reactors

et al. 2004

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The application of microstructured reactors in the chemical process industry has gained significant importance in recent years. Companies that offer not only microstructured reactors, but also entire chemical process plants and services relating to them, are already in existence. In addition, many institutes and universities are active within this field, and process-engineering-oriented reviews and a specialized book are available. Microstructured systems can be applied with particular success in the investigation of highly exothermic and fast reactions. Often the presence of temperature-induced side reactions can be significantly reduced through isothermal operations. Although microstructured reaction techniques have been shown to optimize many synthetic procedures, they have not yet received the attention they deserve in organic chemistry. For this reason, this Review aims to address this by providing an overview of the chemistry in microstructured reactors, grouped into liquid-phase, gas-phase, and gas-liquid reactions.

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Section: Methodsmentioning

confidence: 98%

Section: Perspectives For Reactions In Microstructured Reactorsmentioning

confidence: 99%

Chemistry in Microstructured Reactors

et al. 2004

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“…As a last example for notable yield enhancement via use of micro reactors, the Michael addition shall be cited here [16] (see Scheme 15).…”

Section: Increases In Conversion and Selectivitymentioning

confidence: 99%

Organic Synthesis with Microstructured Reactors

Hessel¹,

Löwe²

2005

Chem Eng & Technol

103

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This article describes the opportunities microstructured reactors offer for chemical plant engineering. This suitability for chemical production is commonly regarded to be the key to market penetration. Century-long practices with batch-type stirring and, correspondingly, the existence of capital-intensive large-scale plants, hinder an easy and fast implementation of chemical micro process engineering. Seen in the long term, there is potential that new plants can be equipped with microstructured reactors. Only economic balances, however, which draw up profitability, will open the door to the usage of chemical micro process engineering for plant construction. The main arguments for using microstructured reactors are enhanced conversion and selectivity, increased space-time yields, waste reduction and better safety given the small reactor volumes. Credit-card sized reaction systems allow one to perform the screening of multi-step reactions in one run. Even more impressively, similar screening is carried out for single-step reactions faster and more reliably. Moreover, safe processing with microstructured reactors in the explosive regime enlarges the traditional range of processing. The reaction guidance by microstructured reactors can further influence subsequent processing steps, such as product purification, and in this way can lower the energy costs of processes.

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“…[80,88] Es wurden auch zahlreiche Fluorierungen, [34,[89][90][91][92][93] Chlorierungen, [48] Nitrierungen, [32,36,[94][95][96][97] Hydrierungen [98][99][100][101] und Oxidationen [39,40,56,[102][103][104][105][106][107][108][109][110] beschrieben. Unter diesen Umsetzungen finden sich Additionen, [56,102,105,106,111] Eliminierungen, [74,99,[112][113][114][115][116] nucleophile Substitutionen an Aliphaten, [117] elektrophile Substitutionen an Arenen, [34,91,[94][95][96] Cycloadditionen …”

Section: Geometrische Parameter Und Prozessgrößen Von Mikrostrukturreunclassified

Chemie in Mikrostrukturreaktoren

et al. 2004

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Mikrostrukturreaktoren haben in den letzten Jahren in der chemischen Verfahrenstechnik deutlich an Bedeutung gewonnen: Erste Firmen, die Prozessanlagen mit Mikrostrukturreaktoren anbieten, sind am Markt, eine Reihe von Instituten erforscht dieses Gebiet, Universitäten bieten Lehrveranstaltungen an, und einige verfahrenstechnisch orientierte Übersichtsartikel liegen bereits vor. Mikrostrukturierte Systeme sind besonders wertvoll für die Untersuchung stark exothermer schneller Reaktionen. Durch isotherme Betriebsweise lassen sich viele thermisch induzierte Nebenreaktionen zurückdrängen, was sicherheitstechnische Vorteile bei Reaktionen mit gefährlichen Reaktanten bringt. Obwohl viele organische Synthesen mit besseren Ergebnissen als in konventionellen Reaktoren durchgeführt wurden, ist der Mikrostrukturreaktor‐Technologie der große Durchbruch in der präparativen Chemie noch nicht gelungen. Aus diesem Grund unterstreicht dieser Aufsatz die Vorteile von Mikrostrukturreaktoren bei Flüssigphasen‐, Gasphasen‐ und Gas‐Flüssigphasen‐Reaktionen.

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1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor

Cited by 48 publications

References 8 publications

Chemistry in Microstructured Reactors

Chemistry in Microstructured Reactors

Organic Synthesis with Microstructured Reactors

Chemie in Mikrostrukturreaktoren

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