1,4‐Dinitrobutane

Abstract

1,4‐Dinitrobutane product: 1,4‐dinitrobutane product: 1,6‐dinitrohexane product: 1,3‐Dinitropropane product: 1,5‐Dinitropentane

The First Conversion of Primary Alkyl Halides to Nitroalkanes under Aqueous Medium

“…), 3a,4c, and (iii) by nitration of the alkyl halides with metal nitrites. For the latter method, silver nitrite in diethyl ether (Victor−Meyer reaction), potassium nitrite, or sodium nitrite in N,N -dimethylformamide (DMF) or in dimethyl sulfoxide (DMSO) (Kornblum reaction) have been frequently used. , The conversion of alkyl halides to nitro compounds is one of the most used methods for the preparation of nitroalkanes; any way, long-reaction times, the use of toxic solvents, and tedious workup are demanded and/or low yields are obtained. Moreover, a further and serious drawback is that the obtained products are usually a mixture, difficult to purify, of the desired nitroalkanes together with the undesired alkyl nitrites.…”