1,4-Naphthoquinone-coated black carbon nanoparticles up-regulation POR/FTL/IL-33 axis in THP1 cells

Cui, Yuan; Li, Zekang; Xiao, Qianqian; Ge, Jianhong; Jiang, Wanyu; Wang, Xiaoyun; Wang, Zhenyu; Yuan, Yuese; Zhuang, Yimeng; Hao, Weidong; Jiang, Jianjun; Meng, Qinghe; Wei, Xuetao

doi:10.1016/j.ecoenv.2022.114381

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…However, the other AOP related research in China focused more on the pharmacy and environment rather than food safety. To give a few examples, Chai et al (2021) generated the AOPs of male reproductivity toxicity of inorganic arsenic; the research group of Wei studied different impairment mechanisms induced by black carbon, a typical environment pollutant, which contributed to the AOP of black carbon (Li et al, 2022b;Jiang et al, 2022c;Cui et al, 2023); Peng et al (2021) overviewed the AOP of drug-induced liver injury. The collaboration between CFSA and the research institutions on the transformation of the related research into the field of food safety is the next step task of CFSA.…”

Section: Adverse Outcome Pathway (Aop)mentioning

confidence: 99%

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

Yang,

Shi

et al. 2023

Front. Toxicol.

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Novel techniques and methodologies are being developed to advance food safety risk assessment into the next-generation. Considering the shortcomings of traditional animal testing, new approach methodologies (NAMs) will be the main tools for the next-generation risk assessment (NGRA), using non-animal methodologies such as in vitro and in silico approaches. The United States Environmental Protection Agency and the European Food Safety Authority have established work plans to encourage the development and application of NAMs in NGRA. Currently, NAMs are more commonly used in research than in regulatory risk assessment. China is also developing NAMs for NGRA but without a comprehensive review of the current work. This review summarizes major NAM-related research articles from China and highlights the China National Center for Food Safety Risk Assessment (CFSA) as the primary institution leading the implementation of NAMs in NGRA in China. The projects of CFSA on NAMs such as the Food Toxicology Program and the strategies for implementing NAMs in NGRA are outlined. Key issues and recommendations, such as discipline development and team building, are also presented to promote NAMs development in China and worldwide.

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Section: Adverse Outcome Pathway (Aop)mentioning

confidence: 99%

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

Yang,

Shi

et al. 2023

Front. Toxicol.

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“…30,31 The MAPK pathway is closely linked to mitochondrial apoptosis. Mitochondrial dysfunction can cause increased intracellular ROS production, 32 which regulates the MAPK signaling pathway. 33 At the same time, cytochrome c (Cyt-C) and apoptosis-inducing factor (AIF) are entered into the cytoplasm, activating downstream apoptotic signals and thus triggering apoptosis.…”

mentioning

confidence: 99%

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Wang,

Sun,

et al. 2023

Environmental Toxicology

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Imidacloprid (IMI) is a neonicotinoid insecticide with the highest global market share, and IMI exposure in the environment can negatively affect many nontarget organisms (a general term for organisms affected by drugs other than target organisms). Resveratrol (RSV), a non‐flavonoid polyphenolic organic compound derived from peanuts, grapes, and other plants, has anti‐inflammatory and antioxidant effects. It is currently unclear how RSV protects against cell damage caused by IMI. Therefore, we established an experimental model of chicken lymphocyte lines exposed to 110 μg/mL IMI and/or 0.5 μM RSV for 24 h. According to the experimental results, IMI markedly raised intracellular reactive oxygen species levels and diminished the activity of the cellular antioxidant enzymes (CAT, SOD, and GPx), leading to MDA accumulation and decreased T‐AOC. JNK, ERK, and P38, the essential components of the mitogen‐activated protein kinase (MAPK) signaling pathway, were also expressed more when IMI was present. Additionally, IMI resulted in upregulation of mitochondrial apoptosis (Caspase 3, Caspase 9, Bax, and Cyt‐c) and necroptosis (Caspase 8, RIPK1, RIPK3, and MLKL) related factors expression, downregulation of Bcl‐2 expression, induction of upregulation of cytokine IL‐6 and TNF‐α expression, and downregulation of IFN‐γ expression. The combined treatment of RSV and IMI significantly reduced cellular oxidative stress levels, inhibited the MAPK signaling pathway, and alleviated IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction. To summarize, RSV antagonized IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway.

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The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review

Bao,

Liu,

Wang

et al. 2024

Arch Toxicol

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1,4-Naphthoquinone-coated black carbon nanoparticles up-regulation POR/FTL/IL-33 axis in THP1 cells

Cited by 8 publications

References 31 publications

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review

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