1-(4-Nitrophenyl)-3-pivaloylthiourea

This review provides an overview of the chemistry, structure and potential applications of 1-(acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R 1 C(O)N (1) HC(S)N (3) R 2 R 3 . In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra-and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono-and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure-activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.

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A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

Saeed

Flörke

Erben

2013

Journal of Sulfur Chemistry

198

123

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N-(3-Nitrophenyl)-N′-pivaloylthiourea

et al. 2008

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N-(2,6-Dimethylphenyl)-N′-propanoylthiourea

Yusof¹,

Mutalib²,

Arshad³

et al. 2012

Acta Cryst E

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In the title compound, C12H16N2OS, an intramolecular N—H⋯O hydrogen bond forms an S(6) ring motif. The propionylthiourea group is approximately planar [with a maximum deviation of 0.135 (2) Å] and forms a dihedral angle of 83.39 (7)° with the benzene ring. In the crystal, molecules are linked by pairs of N—H⋯S hydrogen bonds, forming centrosymmetric dimers and generating R 2 2(8) ring motifs.

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1-(4-Nitrophenyl)-3-pivaloylthiourea

Cited by 3 publications

References 5 publications

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas

N-(3-Nitrophenyl)-N′-pivaloylthiourea

N-(2,6-Dimethylphenyl)-N′-propanoylthiourea

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