“…Considerable efforts have been made to characterize shikimate-and quinate-related enzymes on a threedimensional (3D) level and rationalize the structural principles underlying the details of their enzymatic profiles. In fact, for all enzymes of the shikimate pathway, structural information was published (Stallings et al, 1991;Carpenter et al, 1998;Gourley et al, 1999;Shumilin et al, 1999;Roszak et al, 2002;Maclean and Ali, 2003) as well as for CglQSDH, PDB-ID 2NLO (Schoepe et al, 2008). However, although only an apo-structure is available for the latter, the aforementioned homologues from the AroE, YdiB, SDH-L, Ael1, and Rifl classes were extensively structurally characterized both as apo-enzymes and as binary complexes, but often as well as ternary complexes using various natural sources such as E. coli (Michel et al, 2003), Methanococcus jannaschii (Padyana and Burley, 2003), H. influenzae (Ye et al, 2003), Aquifex aeolicus (Gan et al, 2007), Thermus thermophilus (Bagautdinov and Kunishima, 2007), Staphylococcus epidermis (Han et al, 2009), and Pseudomonas putida (Peek et al, 2011).…”