1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl)methylene]hydrazine: a potent compound against cancer

7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones

“…7-Chloroquinoline hydrazones have been previously developed and successfully tested in vitro for many biological activities [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The major part of the studies has been carried out to identify their antimalarial properties [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

“…The major part of the studies has been carried out to identify their antimalarial properties [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. In addition, these hydrazones were explored for their anti-leishmanial [ 10 , 11 , 12 , 13 ], anti-tubercular [ 3 , 14 , 15 , 16 , 17 , 18 ], anti-bacterial [ 19 , 20 ], anti-oxidant [ 21 , 22 ], anti-fungal [ 23 , 24 ], anti-viral [ 25 ], anti-inflammatory [ 26 ], anti-prion disease [ 27 ], anti-convulsant [ 28 ], antinociceptive [ 29 ], but also anticancer activities [ 30 , 31 , 32 , 33 ]. Many chemical modulations have been realized on 7-chloroquinoline hydrazones.…”

“…Hydrazone I inhibited the growth of SF-295 CNS cancer cells with an IC50 value of 0.688 µg/cm −3 ( Figure 1 ) [ 30 ]. Only one report described molecules containing a heterocyclic unit in addition to the 7-chloroquinoline ring as promising anti-proliferative agents, with notable cell growth inhibition of melanoma MDA-MB-435 cells [ 33 ]. The best antitumor activity was obtained using a pyrrole unit (compound II , Figure 1 ).…”

“…The best antitumor activity was obtained using a pyrrole unit (compound II , Figure 1 ). The latter compound was four times more active than reference Doxorubicin [ 33 ]. This work aims to explore additional heterocyclic units for the improvement of the antitumoral activity of final compounds on the NCI-60 cancer cell line panel.…”

Synthesis and Characterization of Chemical Compounds Derived From Benzohydrazide and Evaluation of Their Antibacterial Activities

“…methanol for antioxidant and cytotoxic properties (14), 2-chloro-3-(l, 3-dioxolan-2-yl) quinolines for DPPH free radical scavenging activities (15), 2-chloro quinoline-3-carbaldehyde derived Schiff bases for antimicrobial activities (16), 7-chloro-4-quinolinylhydrazone derivatives for antitumoral properties (17), N-(2-(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives for fighting with Zika virus function (18), 1-(7-Chloroquinolin-4-yl)-2-[(1H-pyrrol-2-yl) methylene] hydrazine as an anticancer agent (19), 4-[(p-Aminobenzenesulfonamide-N 1 -(2′pyridinil)]-7-chloroquinoline derivatives as promising antimalarial compounds (20), and finally natural and synthetic chloroquinolone derivatives for in vivo and in vitro antioxidant features (21). Some review articles have also inspected the chemical reactions, synthetic methods, and biological properties of 2-chloroquinoline-3-carbaldehyde in the articles published between the years 1979-2017 (22)(23)(24).…”