1,8-Bis(dimethylamino)naphthalene bis[6-fluoro-2-(trifluoromethyl)-4-quinolinol] acetonitrile solvate

Abstract

In the crystal structure of the title compound, ( 1 -dimethylamino-8-naphthyl) dimethyl ammonium 6-fluoro-2-(trifluoromethyl) -4-quinolinolate 6 -fluoro -2-(trifluoromethyl)-4-quinolinol acetonitrile solvate, CI4HI9N~"CIoH4FaNO-'CIoHsF4NO'C2H3N,

tert-Butyl 6-amino-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate

“…The title molecule of (I) contains a benzene ring fused to an oxazine ring and one tert-butoxycarbonyl bound to the N atom. The N1-C1 bond distance is 1.4230 (14)Å and agrees with literature values (Vergeer, et al, 1999;Chen, et al, 2003;Olmstead, et al, 2003). The six-membered heterocyclic ring adopts a half-chair conformation with atoms C7 and C8 lying out of the plane through the remaining four atoms by 0.3264 14and -0.4174 13 Table 1.…”

“…For the pharmacological properties of phenylmorpholine derivatives, see: Albanese et al (2003); La et al (2008); McCormick et al (2008). For related structures, see: Chen et al (2003); Olmstead et al (2003); Vergeer et al (1999). Mo K radiation = 0.09 mm À1 T = 103 K 0.37 Â 0.27 Â 0.21 mm…”

tert-Butyl 6-acetamido-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate

“…The title molecule of (I) contains a benzene ring fused to an oxazine ring and one tert-butoxycarbonyl bound to the N atom. The N1-C8 bond distance is 1.4208 (18) Å and agrees with literature values (Vergeer, et al, 1999;Chen, et al, 2003;Olmstead, et al, 2003). The conformation of the six-membered heterocyclic ring shows that C1 and C2 are out of the plane of the remaining four atoms by 0.5950 16and -0.0818 (16) Å, respectively.…”

“…For the pharmacological properties of phenylmorpholine derivatives, see: Bourlot et al (1998); Albanese et al (2003); La et al (2008). For structures, see: Chen et al (2003); Olmstead et al (2003); Vergeer et al (1999). (2) 168Symmetry codes: (i) x þ 1 2 ; y; Àz þ 3 2 ; (ii) Àx þ 3 2 ; y þ 1 2 ; z.…”

A Survey of Cocrystals Reported Prior to 2000

“…145 Even some noncarboxylic acid salts exist as 1:1 acid:acid salt cocrystals, as does the proton sponge salt of an acidic quinolinol (59). 146 Not all known acid:acid salt cocrystals have a simple 1:1 ratio of components. For example, oxalic acid and pyridine form a cocrystal containing 1 mol of the mono salt and 1 mol of the free acid (Table 2), 178 as well as a cocrystal containing 2 mol of the mono salt and 1 mol of the free acid.…”