1,8-Naphthyridines II: synthesis of novel polyfunctionally substituted 1,8-naphthyridinones and their degradation to 6-aminopyridones

Antimycobacterial, Molecular Docking and ADME Studies of Spiro Naphthyridine Pyrimidine and N‐(Quinolin‐8‐yl)acetamide Derivatives

“…Naphthyridine systems being nitrogen‐rich hybrids [13] are also known for their chemical and biological activities [14–16] . These derivatives are used as potent acyl−CoA: cholesterol acyltransferase inhibitor, [17] anticancer, [18] anti‐inflammatory, [19] antiplatelet, [20] for alzheimer's disease treatment, [21] HIV‐1 integrase inhibitors [22] and antimicrobial [23] agents.…”

“…Naphthyridine systems being nitrogen-rich hybrids [13] are also known for their chemical and biological activities. [14][15][16] These derivatives are used as potent acylÀ CoA: cholesterol acyltransferase inhibitor, [17] anticancer, [18] anti-inflammatory, [19] antiplatelet, [20] for alzheimer's disease treatment, [21] HIV-1 integrase inhibitors [22] and antimicrobial [23] agents. Among the different naphthyridine systems, the development of new synthetic methods remains an active research area in synthesizing 1,8-naphthyridine derivatives [24] because of their physiology such as anti-inflammatory, [25] antitumor, [26,27] and antimycobacterial activities.…”

Microwave-Assisted Synthesis of Novel Pyrazolo[3,4-g][1,8]naphthyridin-5-amine with Potential Antifungal and Antitumor Activity

“…Due to their biological and synthetic importance, the development of effective routes to synthesize naphthyridines continues to be an active area of research for synthetic organic chemists [11]. A survey of the literature shows that the major synthetic approaches used to prepare the naphthyridine system involved condensation of 2-aminopyridine derivatives with carbonyl compounds containing an activated methylene group [12,13,14,15,16,17,18,19] or with β -ketoesters [20].…”