1,8-Naphthyridines IV. 9-Substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities

Synthesis, crystal structure, ABTS radical-scavenging activity, antimicrobial and docking studies of some novel quinoline derivatives

“…The utility of quinoline derivatives in the areas of medicine [1], food, catalyst, dye [2], materials, refineries and electronics [3,4] is well established. These compounds are found to possess various bioactivities such as anti-malarial [5][6][7], anti-bacterial [8][9][10][11], anti-fungal [12][13][14], anti-cancer agents [15][16][17][18]. They are widely used as antibiotics [19], alkaloids, rubber, chemicals and flavoring agents.…”

A Facile Synthesis of 9,10-Dimethoxybenzo[6,7]- ox-epino[3,4-<i>b</i>]quinolin-13(6<i>H</i>)-one and Its Derivatives

“…Quinoline-fused ring systems are a back-bone of many natural products and pharmacologically significant compounds and display a broad range of biological activities [1][2][3], including antiasthmatic [4][5][6], antibacterial [7,8], anti-inflammatory [9] and antihypertensive [10,11] properties. In addition to the medicinal applications, quinolines have been employed in the study of bioorganic and bioorganometallic processes [12].…”

One‐Pot Synthesis of Quinoline Derivatives Directly from Terminal Alkynes via Sequential Ruthenium(II) and Acid Catalysis

“…Applications of quinolines in medicinal chemistry include their use as antimalarial, [1] antileishmanial, [2] anti-inflammatory, [3] antiasthmatic, [4] antibacterial, [5] antihypertensive, [6] tyrosine kinase inhibitory agents, [7] histamine H 3 receptor inverse agonists [8] and for the treatment of estrogen-dependent diseases. [9] Quinoline-based polymers have been produced for applications as thermally stable transparent materials in the fields of electronics, optoelectronics and non-linear optics.…”

“…[23] This catalytic transformation of allyl ketones into furans led us to study the formation of nitrogen-containing heterocycles from alkynes via their sequential catalytic transformations. Herein, we now wish to report the new one-pot sequential ruthenium Cp*RuA C H T U N G T R E N N U N G (NCMe) 3 + BF 4 À and paratoluenesulfonic acid (p-TSA) catalyzed synthesis of 2-substituted 3-arylquinolines directly from terminal alkynes and aniline derivatives [Eq. (3)].…”

“…We then evaluated the influence of p-TSA acid and Cp*RuA C H T U N G T R E N N U N G (MeCN) 3 + PF 6 À catalysts and temperature on this reaction in the absence of Cu(II) salt, by using the allylic ketone 4a and p-toluidine 2a with molecular sieves. The results leading to the formation of 3a are reported in Table 1.…”