1-Acetyl-2-phenylhydrazine carcinogenesis in mice

Tóth, Béla

doi:10.1038/bjc.1979.105

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…39:884, 1980). Recent experiments have demonstrated that 3-N[(y-L-(4)-glutamyl]-4hydroxymethylphenylhydrazine (agaritin), a secondary metabolite of several species of the edible mushroom Agaricus, may be converted to carcinogenic molecules (12,26,28,30,31).…”

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confidence: 99%

Mutagenicity and toxicity of carcinogenic and other hydrazine derivatives: correlation between toxic potency in animals and toxic potency in Salmonella typhimurium TA1538

Malca-Mor¹,

Stark²

1982

Appl Environ Microbiol

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Eleven hydrazine derivatives and an aromatic amine were examined for mutagenicity and toxicity to Salmonella typhimurium. Phenylhydrazine, 2-nitrophenylhydrazine, 4-nitrophenylhydrazine, 2,4-dinitrophenylhydrazine, p-tolylhydrazine, and 4-nitroaniline were found to be frameshift mutagens (strain TA1538). Benzylhydrazine, m-hydroxybenzylhydrazine, p-hydrazinobenzoic acid, L-tyrosine hydrazide, p-aminobenzoyl hydrazide, and isoniazid were not mutagenic. All chemicals were toxic to strain TA1538. A qualitative correlation was found between the pK of the compounds and their mutagenicity. Relative toxicities of hydrazines to bacteria were found to be closely correlated with the relative toxicities of the same compounds in animals. Described herein is a methodology for the rapid prescreening of chemicals which may be used as drugs for those with a high benefit/risk ratio.

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confidence: 99%