1983
DOI: 10.1073/pnas.80.18.5583
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1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism.

Abstract: Extensive fusion was induced in mouse alveolar macrophages by treatment with conditioned media obtained from spleen cell cultures treated with 15 ,ug of phytohemagglutinin or concanavalin A per ml or with 12 nM la,25-dihydroxyvitamin D3 [la,25(OH)2D31. The fusion rate was 80-90% on day 3. In addition, 1a,25(OH)2D3 added directly to alveolar macrophages induced fusion of about 35% of the cells on day 3, whereas direct addition of phytohemagglutinin and concanavalin A did not enhance fusion at all. When conditio… Show more

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Cited by 147 publications
(66 citation statements)
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“…The induction was dose-dependent with concentrations of la,25-(OH)2D3 from 0.05 to 5.0 ng/ml. Amounts of MT increased with the increase of MT mRNA induced by 1a,25(OH)2D3.…”
mentioning
confidence: 91%
“…The induction was dose-dependent with concentrations of la,25-(OH)2D3 from 0.05 to 5.0 ng/ml. Amounts of MT increased with the increase of MT mRNA induced by 1a,25(OH)2D3.…”
mentioning
confidence: 91%
“…In contrast, few reports have demonstrated differences between intramedullary and extramedullary osteoclast precursors (3,4). In this study, we characterized osteoclast precursors by their responsiveness to signaling via TLRs and TNF-␣.…”
mentioning
confidence: 99%
“…They are large, multinucleated cells located on endosteal bone surfaces and the periosteal surface beneath the periosteum, and they are tightly attached to bone matrix (1). In contrast to mature osteoclasts, precursor cells that have the potential to differentiate into mature functional osteoclasts in culture are widely distributed throughout the body (1,3,4).…”
mentioning
confidence: 99%
“…More than 90%o of the cells in this fraction were positively stained for nonspecific esterase (NSEase). Alveolar macrophages were collected by the tracheobronchial lavage method as reported (10 §To whom reprint requests should be addressed.…”
Section: Preparation Of Hemopoietic Mononuclear Cells and Alveolarmentioning
confidence: 99%