1–Alpha, 25–Dihydroxyvitamin D3 Regresses Endometriotic Implants in Rats by Inhibiting Neovascularization and Altering Regulation of Matrix Metalloproteinase

Yildirim, Basak; Güler, Ömer Tolga; Akbulut, Metin; Öztekin, Özer; Sariiz, Gulcin

doi:10.3810/pgm.2014.01.2730

Cited by 43 publications

(43 citation statements)

References 27 publications

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“…Generally, a regression of the endometriotic implants after VD or VDR agonist treatment has been described mainly using animal models [48,49,50] and several mechanisms are postulated to be involved. For this reason, it is quite surprising that the effect of VD has been investigated on very few cellular functions underlying endometriosis development.…”

Section: Vitamin D and Endometriosismentioning

confidence: 99%

Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Cermisoni

Alteri

Corti

et al. 2018

IJMS

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Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase. Endometrial tissue also expresses the enzymes involved in the metabolism of VD. The potential anti-proliferative and anti-inflammatory effects of VD for the treatment of endometriosis have been investigated in recent years. Treatment of ectopic endometrial cells with 1,25(OH)2D3 could significantly reduce cytokine-mediated inflammatory responses. An alteration of VD metabolism in terms of increased 24-hydroxylase mRNA and protein expression has been demonstrated in endometrial cancer, albeit not consistently. The effect of the active form of the vitamin as an anti-proliferative, pro-apoptotic, anti-inflammatory, and differentiation-inducing agent has been demonstrated in various endometrial cancer cell lines.

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Section: Vitamin D and Endometriosismentioning

confidence: 99%

Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Cermisoni

Alteri

Corti

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…37, 38 Moreover, the VDR agonist elocalcitrol inhibited the development of endometriosis in a mouse model. 39 Interesting results emerged from a recent study on pregnant vitamin D deficient mice.…”

mentioning

confidence: 99%

Vitamin D and aspects of female fertility

Voulgaris

Papanastasiou

Piaditis

et al. 2017

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The role of vitamin D in female reproduction has been intensively examined over the last few decades. A large body of evidence suggests that vitamin D might have beneficial effects on metabolic/hormonal parameters of PCOS and endometriosis, while it appears to be associated with IVF outcomes. However, due to the heterogeneity among observational and interventional studies, no cause-effect relationship has yet been established. The aim of this review is to analyze recent in vitro animal and human studies which examined the association of vitamin D with disease entities affecting female fertility potential. Recent research data strongly imply that vitamin D is implicated in female reproduction and might represent a beneficial and inexpensive therapeutic approach, in combination with first-line medical treatments, to female infertility.

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“…64 Hayvan çalışmaları ise vitamin D uygulaması-nın endometriyotik odaklar üzerinde olumlu etkileri olabileceğine işaret etmiştir. [74][75][76] İlk olarak Mariani ve ark. (2012), valide edilmiş endometriozis fare modeliyle yaptıkları bir çalışmada VDR agonisti elokalsitolün lezyonların gelişmesini engellediği, implantasyon ve transfer olan endometriyal dokuların organizasyonu üzerinde koruyucu etkilerinin bulunduğunu bildirmişlerdir.…”

Section: Vi̇tami̇n D Ve Endometri̇ozi̇sunclassified