[1]Benzofuro[3,2‐b]pyridin‐4‐yl‐amines — Synthesis and Investigation of Activity Against Malaria.

Abstract

Fused pyridine derivativesFused pyridine derivatives R 0450 [1]Benzofuro[3,2-b]pyridin-4-yl-amines -Synthesis and Investigation of Activity Against Malaria. -Compound (IIIc) shows some antimalarial activity. -(GOERLITZER*, K.; MEYER H.; JOMAA, H.; WIESNER, J.; Pharmazie 59 (2004) 6, 443-445; Inst. Pharm. Chem., TU Braunschweig, D-38106 Braunschweig, Germany; Ger., Abstr. Eng.) -C. Oppel

4-(4-Bromophenyl)-3-methyl-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]thieno[2,3-e]pyridine 5,5-dioxide

“…For the bioactivity of thienopyridine derivatives, see: Goerlitzer et al (2004Goerlitzer et al ( , 2000; Kamel et al (2003). For the preparation of the title compound, see: Shi & Yang (2011).…”

“…Data collection: CrystalClear (Rigaku/MSC, 2002); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL. Some synthetic thienopyridine compounds exhibit antimalarial activities (Goerlitzer et al 2004) and act as gyrase inhibitors (Goerlitzer et al 2000). Recently, A-312110, a thienopyridine derivative was also reported as a potent KATP channel opener (Kamel et al 2003).…”

Synthesis of Some 3‐(4‐Aryl‐benzofuro[3,2‐b]pyridin‐2‐yl)coumarins and Their Antimicrobial Screening

“…Benzofuro[3,2‐ b ]pyridines have been reported as endothelin receptor antagonists . Certain benzofuro[3,2‐ b ]pyridine derivatives possess an antibacterial and antimalerial activity . A benzofuro[3,2‐ b ]pyridine, Elbfluorene and its derivatives are interesting leads as cyclin‐dependent kinase inhibitors .…”

Ethyl 13-(4-chlorophenyl)-11-methyl-6-oxo-5-phenyl-8-thia-3,4,5,10-tetraazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,10,12-pentaene-12-carboxylate

“…Thienopyridines have been reported to be antimalarial (Gö rlitzer et al, 2004), anti-platelet (Girija et al, 2011) and anti-microbial agents. As part of our studies in this area, we report here the synthesis and the crystal structure of the title compound (Fig.…”