1-Benzoyl-2(<i>S</i>)-<i>tert</i>-butyl-3-methylperhydropyrimidin-4-one

Juaristi, Eusebio

doi:10.1002/047084289x.rn00018

Cited by 3 publications

(2 citation statements)

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“…The work described above (sketched in Figure , ) attracted the attention of a significant number of chemists and biologists, who contributed to the development of numerous novel protocols for the asymmetric synthesis of β-amino acids, as well as applications in biological projects.…”

Section: A Path Marked By Curiosity Obstinacy and Serendipitymentioning

confidence: 99%

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Looking for Treasure in Stereochemistry-Land. A Path Marked by Curiosity, Obstinacy, and Serendipity

Juaristi

2012

J. Org. Chem.

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Over the past 40 years, much of my research has evolved around various topics of conformational analysis and asymmetric synthesis. This Perspective describes some of my salient contributions in eight different areas of organic stereochemistry: (1) conformational analysis of six-membered rings, (2) evaluation of stereoelectronic interactions in (1)J(C-H) one-bond coupling constants in six-membered rings, (3) eclipsed conformation in cis-2-tert-butyl-5-(tert-butylsulfonyl)-1,3-dioxane, (4) determination of enthalpic and entropic contributions to ΔG°(CH(2)Ph) and ΔG°(t-Bu), (5) study of the "attractive gauche effect" in O-C-C-O segments, (6) examination of salt effects on conformational equilibria, (7) asymmetric synthesis of β-amino acids, and (8) asymmetric organocatalysis and "Green" chemistry. It will be appreciated that a basic understanding of the principles of physical organic chemistry has been essential in all projects. Furthermore, curiosity, enthusiasm, obstinacy, and paying attention to unexpected observations will lead to many new (stereo)chemical discoveries.

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Section: A Path Marked By Curiosity Obstinacy and Serendipitymentioning

confidence: 99%

“…Pyrimidinone ( S )- 34 as convenient substrate for the enantioselective synthesis of β-amino acids, β-lactams, and cyclo-β-dipeptides. , …”

Section: A Path Marked By Curiosity Obstinacy and Serendipitymentioning

confidence: 99%