This qualitative study utilized a thematic six-step analysis process of interview data to identify prominent themes in the life experiences of 20 Uzbek immigrants regarding their migration to and resettlement in the United States; it also examined gender differences in their experiences. The results indicated that at the time of migration, most Uzbek participants were well-educated, middle class, and in their mid-20s. The primary reasons for their migration were limited socioeconomic and employment opportunities, and the declining educational quality in Uzbekistan. Uzbek participants reported some difficulties in their resettlement, including language barriers, cultural challenges, and financial stress. Most participants felt welcomed by the host community, believed in the “American dream,” considered themselves successful, and envisioned their future in the US rather than in Uzbekistan. Across all interview questions, women tended to focus on their children’s well-being and the opportunity to gain personal freedom in terms of education and employment, whereas career aspirations and achievement of financial stability were the focus for men. The results from this study provide much-needed information about the life experiences of Uzbek immigrants in the US and have implications for future research with this understudied population from Central Asia.