1-Bromo-1-chloro-2,2,2-trifluoroethane (Halothane) as a building block for fluorine compounds

Reductive Bromine Atom-Transfer Reaction

“…The reaction proceeded well, but to our surprise it gave the reduced addition products 4 rather than 3 as major product (Scheme , eq 2). A literature survey showed that only one precedence exists for “reductive” ATR reaction, which was found in the reaction of 1-bromo-1-chloro-2,2,2-trifluoroethane and allylaromatics with sodium dithionite in MeCN/H 2 O solution . In this paper, we present the unusual reductive ATR reaction, which serves as the hydroalkylation of alkenes.…”

1,2-Dibromotetrafluoroethane (Freon 114B2) as a building block for fluorine compounds

“…The first announcement on the synthetic application of 1,2-dibromotetrafluoroethane was that by Rico and Wakselman [3] who reported its reactions with potassium thiophenoxides in dimethylformamide (DMF) leading to mixtures of aryl 2-bromotetrafluoroethyl thioethers (1) and their reduction products, 1,1,2,2-tetrafluoroethyl thioethers (2). Similarly, reactions with potassium phenoxides gave mixtures of 2-bromotetrafluoroethyl ethers (3) and 1,1,2,2-tetrafluoroethyl ethers (4).…”

“…In the preceding paper [1] numerous applications of 1-bromo-1-chlorotrifluoroethane (Halothane) as a building block for the synthesis of fluorine compounds have been summarized. Another synthetically useful, readily available and not expensive compound for such purpose is 1,2-dibromotetrafluoroethane.…”

Facile synthesis of (E)-β-(trifluoromethyl)styrenes from halothane (HCFC-123B1)

“…However, the development of the relevant b-(trifluoromethyl)styrenes remains unexplored. Therefore, we considered the use of halothane (HCFC-123B1) instead of the polyhalogenalkanes, employed by Nenajdenko et al, to afford the corresponding b-(trifluoromethyl)styrenes under similar reaction conditions [33]. We report herein the practical synthesis of b-(trifluoromethyl)styrenes using halothane as a trifluoroethylidene (CF 3 CH5 5) source.…”