1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat–fed mice

Ju, Hyun; Chung, Ji Hyung; Hwang, Ji Won; Kim, Oh Yoen; Lee, Jae Yeon; Shin, Min Jeong

doi:10.1016/j.fct.2014.11.001

Cited by 48 publications

(34 citation statements)

References 44 publications

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“…Dietary supplementary Cr and B. subtilis could improve body lipid metabolism [19–21]. Our data suggested that the concentration of plasma total cholesterol and triglycerides were decreased in chicken treated with CEBS or B. subtilis .…”

Section: Discussionmentioning

confidence: 75%

Effects of chromium-enriched bacillus subtilis KT260179 supplementation on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality

et al. 2016

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BackgroundBoth chromium (Cr) and probiotic bacillus own the virtues of regulating animal metabolism and meat quality. Purpose of this study was to evaluate the efficiency of supplemental Cr and bacillus in the form of chromium-enriched Bacillus subtilis KT260179 (CEBS) on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality.MethodsSix hundred of 1-day-old Chinese Huainan Partridge chickens were divided into four groups randomly: Control, inorganic Cr, Bacillus subtilis, and CEBS. The feed duration was 56 days.ResultsAfter 28 days of treatment, broiler feed CEBS or normal B. subtilis had higher body weights than control broiler, and after 56 days, chickens given either CEBS or B. subtilis had greater body weights than control broiler or those given inorganic Cr. Plasma total cholesterol, triglycerides, and low density lipoprotein cholesterol levels declined significantly in the CEBS group compared with the control, whereas plasma high density lipoprotein cholesterol levels increased significantly. The concentration of Cr in blood and breast muscle increased after CEBS and inorganic Cr supplementation. B. subtilis and CEBS supplementation caused a significant increase in the numbers of Lactobacillus and Bifidobacterium in the caecum, while the numbers of Escherichia coli and Salmonella decreased significantly compared to the control. Feed adding CEBS increased the lightness, redness, and yellowness of breast meat, improved the water-holding capacity, decreased the shear force and cooking loss.ConclusionsIn all, CEBS supplementation promoted body growth, improved plasma lipid parameters, increased tissue Cr concentrations, altered cecal bacterial composition and improved breast meat quality.

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Section: Discussionmentioning

confidence: 75%

Effects of chromium-enriched bacillus subtilis KT260179 supplementation on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality

et al. 2016

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“…The leaves of the mulberry tree are known worldwide as sources of phytotherapeutics, which have been used for the treatment of conditions related to diabetes and been recorded based on clinical trials or the use of animal models (Banu et al, ; El‐Sayyed, Badawy, Elnabi, El‐Elaimy, & Shehari, ; Zhang et al, ). A large number of animal and human studies in vivo suggested that mulberry leaves has the antidiabetic and its complications activity (Andallu & Varadacharyulu, ; Do et al, ; Volpato et al, ; Zhang et al, ). Many different types of constituents in mulberry leaves have been linked to prevention and treatment of diabetes and its complications (Guo et al, ; Li et al, ; MA et al, ).…”

Section: Introductionmentioning

confidence: 99%

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

Zhu

et al. 2019

Phytotherapy Research

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Mulberry leaf was reported that it has antidiabetic activity, although the mechanisms underlying the function have not been fully elucidated. In the present study, the results of network pharmacology suggested that mulberry leaves could regulate key biological process in development of diabetes, and the process implicates multiple signaling pathways, such as JAK-STAT, MAPK, VEGF, PPAR, and Wnt. Then, the research in vitro indicated that mulberry leaves remarkably ameliorated high glucose-induced epithelial to mesenchymal transition, which was characterized with significant reduction of intracellular reactive oxygen species (ROS) levels as well as downregulation of NADPH oxidase subunits NOX1, NOX2, and NOX4, and it was found to be connected with the ERK1/2 signaling pathway in human tubular epithelial cells (HK-2). Moreover, the results of bioinformatics and the dual luciferase report showed that ZEB1 might be a target gene of miR-302a; decreased miR-302a and increased ZEB1 expressions could significantly promote epithelial to mesenchymal transition. However, mulberry leaves could reverse these modulations. Our results demonstrated that network pharmacology could provide a guidance role for traditional Chinese medicine research, and mulberry leaves could be of benefit in preventing high glucose-induced EMT in HK-2 cells, which proved that it was related to the upregulation of miR-302a by targeting ZEB1 and the inhibition of NADPH oxidase/ROS/ERK1/2 pathway.

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“…In general, according to the DPPH assay, the radical scavenging activity can be evaluated by measuring the concentration of the DPPH solution in which the radical is scavenged after adding an antioxidant to the DPPH solution and alloying a 30-minute reaction time. 35,36 However, since antioxidants exhibit various trends and reaction rates in DPPH radical scavenging activity, there are some limitations in using the DPPH assay to assess the characteristics of the antioxidant activity of substances. [37][38][39] Thus, to analyze the characteristics of the antioxidant scavenging activity of the extracts and the scavenging rates during the initial reaction, plots were prepared of the amounts of scavenged radical versus reaction times using the extracts [40][41][42] (Fig.…”

Section: Dpph Radical Scavenging Activity Of the Extractsmentioning

confidence: 99%

Evaluation of Antioxidant Activity of Amaranthus Hypochondriacus L. Extract Using Cyclic Voltammetry

et al. 2019

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The antioxidative activity of the extracts from amaranth flower and leaves was characterized using 1,1-diphenyl-2picrylhydrazyl (DPPH) method and cyclic voltammetry. It was found that the extracts prepared with amaranth flower (AM-F) showed an improved antioxidative activity compared to the extracts prepared with amaranth leaves (AM-L) using the conventional DPPH method. Furthermore, the antioxidative activities of AM-F and AM-L were evaluated using cyclic voltammetry as an electrochemical method. AM-F exhibited an improved electrochemical oxidation for active oxygen and a fast removal of active oxygen compared to AM-L. In addition, the CV analysis to evaluate antioxidant activity was found to be more accurate, compared to DPPH method.

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1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat–fed mice

Cited by 48 publications

References 44 publications

Effects of chromium-enriched bacillus subtilis KT260179 supplementation on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality

Effects of chromium-enriched bacillus subtilis KT260179 supplementation on chicken growth performance, plasma lipid parameters, tissue chromium levels, cecal bacterial composition and breast meat quality

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

Evaluation of Antioxidant Activity of Amaranthus Hypochondriacus L. Extract Using Cyclic Voltammetry

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