1 H NMR-based metabolomics study of liver damage induced by ginkgolic acid (15:1) in mice

Jiang, Lei; Si, Zhi-Hong; Li, Minghui; Zhao, He; Fu, Yong-Hong; Xing, Yue-Xiao; Wei, Hong; Ruan, Ling-Yu; Li, Pu-Min; Wang, Junsong

doi:10.1016/j.jpba.2016.12.033

Cited by 25 publications

(21 citation statements)

References 39 publications

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“…Ginkgo has been shown to inhibit many cytochrome P450 enzymes, including CYP2C9, CYP1A2, CYP2E1 and CYP3A4 . There is evidence suggesting ginkgolic acid, a constituent of some ginkgo products, can dose‐dependently induce liver injury via increases in ALT and AST . A study published in 2016 showed that ginkgolides A, B and K, all constituents of ginkgo, are distributed to a wide variety of tissues in the bodies of rats .…”

Section: Discussionmentioning

confidence: 99%

“…5 There is evidence suggesting ginkgolic acid, a constituent of some ginkgo products, can dosedependently induce liver injury via increases in ALT and AST. 6 A study published in 2016 showed that ginkgolides A, B and K, all constituents of ginkgo, are distributed to a wide variety of tissues in the bodies of rats. 7 One of the main sites of distribution was the liver, and the ginkgolides were taken up to a lesser extent by the muscle.…”

Section: Discussionmentioning

confidence: 99%

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Rhabdomyolysis after Ginkgo biloba and cannabis

Strain

Yingling

Kraleti

et al. 2019

Pharmacy Practice and Res

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Background Rhabdomyolysis is a syndrome caused by the death of muscle tissue, which leads to the release of the muscle protein myoglobin into the circulation. The severity of rhabdomyolysis varies widely from asymptomatic to life threatening, and has many possible causes, including a specific classification associated with medications. This report suggests the potential for rhabdomyolysis induction by an interaction between ginkgo (Ginkgo biloba) and cannabis, in addition to recent strenuous exercise. Prompt identification of the aetiology and treatment are crucial in preventing complications and mortality. Clinical details A 26‐year‐old African American female presented to the emergency department (ED) with a chief complaint of worsening muscle pain and weakness, 2 days after exercise without adequate hydration. The patient reported recently starting a ginkgo supplement, in addition to her regular medications and confirmed marijuana use. Urinalysis and creatine kinase (CK) data collected in the ED were suggestive of rhabdomyolysis. Outcomes The patient was admitted to hospital. After rehydration with intravenous normal saline, her CK levels and symptoms improved. Conclusion Ginkgo is an increasingly popular natural supplement with a variety of uses. However, the use of this product, with or without cannabis consumption, may correspond to an increased likelihood for interactions and adverse drug reactions, such as the potential for rhabdomyolysis presented here. It is important for pharmacists and other clinicians to be aware of the prospective risks associated with this supplement in order to properly educate patients and mitigate potential morbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis after Ginkgo biloba and cannabis

Strain

Yingling

Kraleti

et al. 2019

Pharmacy Practice and Res

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“…ATP hydrolyzes into ADP or AMP to produce energy for the cell, and IMP can convert into AMP by adenylosuccinate lyase [27]. Interestingly, the ATP level did not significantly increase, so the AMP/ATP ratio increased after treatment with resveratrol, indicating that the balance between the production and consumption of ATP was disturbed [28].…”

Section: Purine Metabolismmentioning

confidence: 99%

Resveratrol inhibits the growth of Xanthomonas oryzae pv. oryzae and the metabolomic analysis

Luo

Guan

et al. 2019

Preprint

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Background Xanthomonas oryzae pv. oryzae ( Xoo ) can cause destructive bacterial leaf blight in rice. As an antibacterial, resveratrol may inhibit Xoo growth. This study focused on the potential structural-activity relationship of resveratrol and its derivatives against Xoo growth, and 1 H-NMR-based metabolomic analysis was applied to investigate the global metabolite changes in Xoo after resveratrol treatment.Results Resveratrol showed the strongest inhibitory effects on Xoo growth compared with its derivatives, which lacked double bonds (compounds 4 – 6 ) or hydroxyls were substituted with methoxyls (compounds 7 – 9 ). The IC 50 of resveratrol against Xoo growth was 11.67 ± 0.58 μg/mL. Results indicated that the double bond of resveratrol contributed to its inhibitory effects on Xoo growth, and hydroxyls were vital for this inhibition. Interestingly, resveratrol also significantly inhibited Xoo flagellum growth. Based on 1 H-NMR global metabolic analysis, a total of 30 Xoo metabolites were identified, the changes in the metabolic profile indicated that resveratrol could cause oxidative stress as well as disturb energy, purine, amino acid, and NAD + metabolism in Xoo , resulting in the observed inhibitory effects on growth.Conclusions This study showed that the double bond of resveratrol contributed to its inhibitory effects on Xoo growth, and hydroxyls were also the important active groups. Resveratrol could cause oxidative stress of Xoo cells, and disturb the metabolism of energy, purine, amino acid and NAD +, thus inhibit Xoo growth.

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“…NMR spectroscopy has several advantages over MS, including high reproducibility, non-destructive analysis, a simple quantification approach, and minimal sample preparation [5]. 1 H-NMR-based metabolomics is currently widely used to gain insights into liver disease mechanisms [6,7] or to evaluate drug hepatotoxicity [8,9] and environmental contaminants [10]. In most studies that used proton NMR-based metabolomics for liver samples, analyses have been performed on either aqueous extracts or lipidic extracts.…”

Section: Introductionmentioning

confidence: 99%

Proton NMR Enables the Absolute Quantification of Aqueous Metabolites and Lipid Classes in Unique Mouse Liver Samples

et al. 2019

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Hepatic metabolites provide valuable information on the physiological state of an organism, and thus, they are monitored in many clinical situations. Typically, monitoring requires several analyses for each class of targeted metabolite, which is time consuming. The present study aimed to evaluate a proton nuclear magnetic resonance (1H-NMR) method for obtaining quantitative measurements of aqueous and lipidic metabolites. We optimized the extraction protocol, the standard samples, and the organic solvents for the absolute quantification of lipid species. To validate the method, we analyzed metabolic profiles in livers of mice fed three different diets. We compared our results with values obtained with conventional methods and found strong correlations. The 1H-NMR protocol enabled the absolute quantification of 29 aqueous metabolites and eight lipid classes. Results showed that mice fed a diet enriched in saturated fatty acids had higher levels of triglycerides, cholesterol ester, monounsaturated fatty acids, lactate, 3-hydroxy-butyrate, and alanine and lower levels of glucose, compared to mice fed a control diet. In conclusion, proton NMR provided a rapid overview of the main lipid classes (triglycerides, cholesterol, phospholipids, fatty acids) and the most abundant aqueous metabolites in liver.

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1 H NMR-based metabolomics study of liver damage induced by ginkgolic acid (15:1) in mice

Cited by 25 publications

References 39 publications

Rhabdomyolysis after Ginkgo biloba and cannabis

Rhabdomyolysis after Ginkgo biloba and cannabis

Resveratrol inhibits the growth of Xanthomonas oryzae pv. oryzae and the metabolomic analysis

Proton NMR Enables the Absolute Quantification of Aqueous Metabolites and Lipid Classes in Unique Mouse Liver Samples

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